Regular Article
Thioredoxin from Activated Macrophages as a Trophic Factor for Central Cholinergic Neurons in Vitro

https://doi.org/10.1006/bbrc.1993.1479Get rights and content

Abstract

The conditioned medium from γ-interferon-stimulated rnacrophages elevated the choline acetyltransferase activity in mouse septal neurons as well as in cholinergic hybrid cell lines SN6.10.2.2 in vitro. After purification and sequencing, the active fraction was identical to thioredoxin (TRX), and the neurotrophic activity of recombinant TRX was confirmed.

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