Biochemical and Biophysical Research Communications
Regular ArticleModulation of Airway Epithelial Cell Ciliary Beat Frequency by Nitric Oxide
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Analysis of motility and mucociliary function of tracheal epithelial cilia
2023, Methods in Cell BiologyUtility of NO and H<inf>2</inf>S donating platforms in managing COVID-19: Rationale and promise
2022, Nitric Oxide - Biology and ChemistryCitation Excerpt :The same has been reported in mouse nasal and tracheal epithelial cells [164]. These actions are mediated through the cGMP pathway [165,166]. Additionally, NO increases mucus secretion, stimulating the feline and human submucosal glands by l-arginine and isosorbide dinitrate enhanced secretion activity [167].
Computational modeling of nasal nitric oxide flux from the paranasal sinuses: Validation against human experiment
2021, Computers in Biology and MedicineCitation Excerpt :Moreover, the paranasal sinuses typically exhibit NO concentrations exceeding those derived directly from the nasal mucosa by 1-2 orders of magnitude [2,3], thereby serving as a “reservoir” of and major contributor to nNO. NO functions importantly in the respiratory system as bronchodilator [4], vasodilator [5], neurotransmitter [6,7], and as an immune modulator involved in regulation of inflammation [8,9] and in surveillance for neoplasia [10–15]. NO is also involved in the response to respiratory pathogens by upregulating mucociliary function [16–18]. Clinically, supplemental NO at levels exceeding physiologic values has been shown to benefit patients with acute respiratory distress syndrome (ARDS) [19] and both adults and newborns with pulmonary hypertension [20,21].
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