Table 4

Significant genes from the interaction term (asthmaRSV−asthmamon-infected)−(healthyRSV−healthynon-infected)

Gene IDGene nameFDRDirection of the change
Basal resting cellsCRCT1Cysteine-rich C-terminal 10.042RSV induced in asthma only
Cycling cellsKRT14Keratin 140.011RSV induced in healthy only
Goblet cellsICAM1Intercellular adhesion molecule 10.011Increased RSV induction in healthy
IL17CInterleukin 17C0.045RSV induced in healthy only
DUSP2Dual specificity phosphatase 20.045RSV induced in healthy only
C11orf96Chromosome 11 open reading frame 960.045RSV induced in healthy only
OASL2’−5’-oligoadenylate synthetase like0.045RSV induced in healthy only
TNFAIP3Tumour necrosis factor alpha-induced protein 30.045Increased RSV induction in healthy
  • Interaction analysis was performed using edgeR, for each cell type. Statistical significance was considered for genes with an FDR <0.05.

  • FDR, false discovery rate; RSV, respiratory syncytial virus.