Table 1

Baseline characteristics of newly diagnosed patients with COPD categorised by baseline LRTI frequency and severity

OverallNone1 mild≥2 mild1 moderate≥2 moderate≥1 severe
Patient, n (%)215 234 (100)158 074 (73.4)18 081 (8.4)6133 (2.8)19 787 (9.2)6227 (2.9)6932 (3.2)
Median study follow-up in years (Q1–Q3)4.4 (1.9–7.8)4.5 (2.0–7.9)3.1 (1.5–5.7)2.9 (1.3–5.2)6.4 (3.3–9.3)6.5 (3.3–9.5)2.4 (0.9–4.8)
Mean age (SD)66.9 (11.4)66.6 (11.3)67.4 (11.5)67.8 (11.6)66.9 (11.2)67.2 (11.4)71.5 (12.0)
Sex
Male114 738 (53.3)86 166 (54.5)8998 (49.8)2921 (47.6)9991 (50.5)2915 (46.8)3747 (54.1)
Female100 496 (46.7)71 908 (45.5)9083 (50.2)3212 (52.4)9796 (49.5)3312 (53.2)3185 (46.0)
Smoking status
Ex-smoker107 787 (50.1)84 066 (53.2)9407 (52.0)3274 (53.4)10 508 (53.1)3324 (53.4)4128 (59.6)
Current smoker107 447 (49.9)74 008 (46.8)8674 (48.0)2859 (46.6)9279 (46.9)2903 (46.6)2804 (40.5)
GOLD grade of airflow limitation
151 151 (23.8)38 450 (24.3)4370 (24.2)1441 (23.5)4627 (23.4)1336 (21.5)927 (13.4)
278 736 (36.6)57 432 (36.3)6757 (37.4)2287 (37.3)7793 (39.4)2537 (40.7)1930 (27.8)
324 985 (11.6)17 764 (11.2)2086 (11.5)724 (11.8)2705 (13.7)859 (13.8)847 (12.2)
43814 (1.8)2781 (1.8)282 (1.6)99 (1.6)361 (1.8)138 (2.2)153 (2.2)
Missing56 548 (26.3)41 647 (26.4)4586 (25.4)1582 (25.8)4301 (21.7)1357 (21.8)3075 (44.4)
mMRC score
134 191 (15.9)25 687 (16.3)3201 (17.7)1000 (16.3)2854 (14.4)779 (12.5)670 (9.7)
259 658 (27.7)43 767 (27.7)5580 (30.9)1967 (32.1)5297 (26.8)1579 (25.4)1468 (21.2)
332 330 (15.0)22 858 (14.5)3118 (17.2)1161 (18.9)2938 (14.9)1001 (16.1)1254 (18.1)
413 249 (6.2)9050 (5.7)1319 (7.3)487 (7.9)1188 (6.0)434 (7.0)771 (11.1)
52559 (1.2)1652 (1.1)279 (1.5)94 (1.5)235 (1.2)78 (1.3)221 (3.2)
Missing73 247 (34.0)55 060 (34.8)4584 (25.4)1424 (23.2)7275 (36.8)2356 (37.8)2548 (36.8)
Myocardial infarction15 062 (7.0)10 599 (6.7)1367 (7.6)467 (7.6)1408 (7.1)491 (7.9)730 (10.5)
Stroke17 311 (8.0)12 381 (7.8)1553 (8.6)588 (9.6)1399 (7.1)458 (7.4)932 (13.4)
Heart failure9136 (4.2)6045 (3.8)951 (5.3)335 (5.5)726 (3.7)303 (4.9)776 (11.2)
Lung cancer412 (0.2)285 (0.2)42 (0.2)<2042 (0.2)<20<20
Asthma45 751 (21.3)33 480 (21.2)3540 (19.6)1285 (21.0)4505 (22.8)1745 (28.0)1196 (17.3)
GORD31 904 (14.8)22 403 (14.2)3154 (17.4)1217 (19.8)3005 (15.2)1067 (17.1)1058 (15.3)
Anxiety disorder46 184 (21.5)32 399 (20.5)4625 (25.6)1678 (27.4)4409 (22.3)1571 (25.2)1502 (21.7)
Depression55 323 (25.7)39 000 (24.7)5358 (29.6)1990 (32.5)5320 (26.9)1839 (29.5)1816 (26.2)
BMI group (in kg/m2)
<198395 (3.9)5996 (3.8)757 (4.2)226 (3.7)735 (3.7)247 (4.0)434 (6.3)
19–2462 392 (29.0)46 015 (29.1)5126 (28.4)1662 (27.1)5919 (29.9)1725 (27.7)1945 (28.1)
25–2964 885 (30.2)48 313 (30.6)5314 (29.4)1802 (29.4)5863 (29.6)1877 (30.1)1716 (24.8)
≥3058 796 (27.3)42 687 (27.0)5251 (29.0)1897 (30.9)5325 (26.9)1781 (28.6)1855 (26.8)
Missing20 766 (9.7)15 063 (9.5)1633 (9.0)546 (8.9)1945 (9.8)597 (9.6)982 (14.2)
IMD quintiles
1 (least deprived)34 469 (16.0)25 774 (16.3)2744 (15.2)896 (14.6)3148 (15.9)909 (14.6)998 (14.4)
238 946 (18.1)28 881 (18.3)3.122 (17.3)1036 (16.9)3589 (18.1)1111 (17.8)1207 (17.4)
342 090 (19.6)31 054 (19.7)3436 (19.0)1206 (19.7)3837 (19.4)1202 (19.3)1355 (19.6)
445 775 (21.3)33 531 (21.2)3913 (21.6)1325 (21.6)4120 (20.8)1335 (21.4)1551 (22.4)
5 (most deprived)53 797 (25.0)38 714 (24.5)4852 (26.8)1669 (27.2)5076 (25.7)1669 (26.8)1817 (26.2)
Missing157 (0.1)120 (0.1)14 (0.1)<517 (0.1)<5<5
Blood eosinophil levels
<300 cells/µL83 244 (38.7)60 574 (38.3)7377 (40.8)2659 (43.4)7340 (37.1)2329 (37.4)2965 (42.8)
≥300 cells/µL37 720 (17.5)26 885 (17.0)3408 (18.9)1272 (20.7)3611 (18.3)1206 (19.4)1338 (19.3)
Missing94 270 (43.8)70 615 (44.7)7296 (40.4)2202 (35.9)8826 (44.7)2692 (43.2)2629 (37.9)
  • The following baseline variables were identified at or close to index date and were identified as ‘current’: age, smoking status, IMD, BMI, mMRC, GOLD, asthma, eosinophil level. The following baseline variables were recorded any time prior to index date: depression, anxiety, GORD, lung cancer, myocardial infarction, heart failure, stroke.

  • BMI, body mass index; COPD, chronic obstructive pulmonary disease; GOLD, Global Initiative for Chronic Obstructive Lung Disease; GORD, gastro-oesophageal reflux disease; IMD, Index of Multiple Deprivation; LRTI, lower respiratory tract infection; mMRC, modified Medical Research Council.