Associations of MUC5B (rs35705950) risk allele with longitudinal changes in high-attenuation areas (HAAs)
| Model | Number of participants | % longitudinal change in HAAs per 10 years (95% CI) per MUC5B (rs35705950) risk allele (T) | P value* |
| Overall | 4552 | 2.60 (0.36 to 4.86) | 0.02 |
| Stratified by telomere length percentile cut-off | |||
| Below 5th percentile | 221 | 15.13 (5.60 to 24.75) | 0.008 |
| Above 5th percentile | 4267 | 1.93 (−0.40 to 4.27) | |
| Below 10th percentile | 446 | 5.26 (−1.35 to 11.91) | 0.41 |
| Above 10th percentile | 4042 | 2.30 (−0.11 to 4.71) | |
| Below 25th percentile | 1119 | 5.03 (0.83 to 9.25) | 0.19 |
| Above 25th percentile | 3369 | 1.72 (−0.94 to 4.38) |
Overall model is adjusted for scanner parameters and principal components of genetic ancestry. Baseline age, sex, self-reported race/ethnicity, smoking status and cigarette pack-years were also adjusted for including their interaction terms with ‘time since initial HAA assessment’. Time-varying covariates height, weight, per cent emphysema and cigarettes smoked per day were also adjusted for in the model.
Stratified models include their respective three-way interaction term (eg, ‘telomere length percentile below 5%×MUC5B risk allele×time since initial HAA assessment’).
All results are reported per risk allele (T) of the MUC5B (rs35705950) promoter variant.
*P values for stratified analysis represent p values for interaction.