Comparison of the test sensitivities of interferon-gamma release assays and the tuberculin skin test (at ≥5 mm and ≥10 mm cut-offs) stratified by disease focus
| Sensitivity (%) | Pairwise comparison (p value) | |||||
| Respiratory TB | Miliary and/or CNS TB | Other focus* | Respiratory versus Miliary and/or CNS | Respiratory versus Other focus* | Miliary and/or CNS versus Other focus* | |
| QFT-Plus | 85.8 | 73.1 | 78.6 | 0.08 | 0.33 | 0.41 |
| QFT-GIT | 86.7 | 70.9 | 87.9 | 0.0019 | 0.76 | 0.008 |
| T-SPOT.TB | 85.4 | 63.6 | 50.0 | 0.10 | 0.04 | <0.0005 |
| TST5 | 90.6 | 67.4 | 97.1 | <0.0005 | 0.03 | <0.0005 |
| TST10 | 84.8 | 43.5 | 94.2 | <0.0005 | 0.011 | <0.0005 |
P values were calculated with Wald χ2 tests; according to Bonferroni correction, p values of <0.017 were considered statistically significant (highlighted in bold).
*Other disease focus comprised: lymph node, osteoarticular, genitourinary, abdominal and pericardial TB.
CNS, central nervous system; QFT-GIT, QuantiFERON-TB Gold in-Tube; QFT-Plus, QuantiFERON-TB Gold-Plus; TB, tuberculosis; TST, tuberculin skin test .