Included data | Brain only model | Brain and non-imaging measures model | Non-imaging measure model |
Drug ID | x | x | x |
Responder or non-responder label | x | x | x |
Brain activity | |||
Amygdala | x | x | |
Hippocampus | x | x | |
Anterior insula | x | x | |
Anterior cingulate | x | x | |
Posterior insula | x | x | |
Putamen | x | x | |
Superior marginal gyrus | x | x | |
Superior frontal gyrus | x | x | |
Precuneus | x | x | |
Medial prefrontal cortex | x | x | |
Caudate | x | x | |
Posterior cingulate | x | x | |
Angular gyrus | x | x | |
Precentral gyrus | x | x | |
Middle frontal gyrus | x | x | |
Questionnaires | |||
D12 | x | x | |
CES-D | x | x | |
TRAIT | x | x | |
FSS | x | x | |
SGRQ | x | x | |
MRC | x | x | |
BCS | x | x | |
Vigilance | x | x | |
Physiology | |||
FEV1/FVC | x | x | |
MSWT—HR change | x | x | |
MSWT—SPO2 change | x | x | |
MSWT—distance | x | x | |
MSWT—BORG change | x | x | |
BMI | x | x | |
Pack-years | x | x | |
Age | x | x | |
Sex | x | x |
Drug ID labels corresponded to whether the participant received D-cycloserine or placebo.
BCS, breathlessness catastrophising scale; BMI, body mass index; BORG, rating of perceived exertion; CES-D, Centre for Epidemiologic Studies Depression Scale; D12, Dyspnoea-12; FEV1, forced expiratory volume; FSS, Fatigue Severity Scale; FVC, forced vital capacity; HR, heart rate; MRC, Medical Research Council; MSWT, Modified Shuttle Walk Test; SGRQ, St George’s Respiratory Questionnaire; SPO2, oxygen saturation; TRAIT, Trait Anxiety Inventory.