Cox regression analysis: the effect of CPAP on MACEs in patients with moderate–severe OSA by clusters (n=1108)
| Cluster 1 | Cluster 2 | Cluster 3 | Cluster 4 | |
| No. of subjects | 333 | 265 | 271 | 239 |
| Incident MACEs, n (%) | 57 (17.1%) | 38 (14.3%) | 46 (17.0%) | 43 (18.0%) |
| Crude HR | 0.49 (0.25 to 0.95) | 0.85 (0.33 to 2.19) | 0.94 (0.45 to 1.95) | 1.18 (0.62 to 2.27) |
| Adjusted HR* | 0.44 (0.22 to 0.85) | 0.85 (0.33 to 2.19) | 0.85 (0.41 to 1.77) | 1.57 (0.79 to 3.13) |
| Adjusted HR† | 0.45 (0.23 to 0.90) | 0.79 (0.30 to 2.12) | 0.68 (0.31 to 1.45) | 1.40 (0.67 to 2.91) |
*Adjusted for age, gender and body mass index.
†Adjusted for age, gender, body mass index, waist circumference, neck circumference, AHI, TST90 and mean heart rate.
AHI, apnoea–hypopnoea index; MACEs, major adverse cardiovascular events; OSA, obstructive sleep apnoea; TST90, sleep time with oxygen saturation below 90%.