Patient and tumour characteristics
| MPM (n=11 539) | MPeM (n=629) | Total (N=12 168) | P value | |
| Age, median (IQR) | 71 (64–77) | 69 (61–76) | 71 (64–77) | 0.004 |
| Male, n (%) | 10 085 (87.4) | 458 (72.3) | 10 543 (86.6) | <0.001 |
| Histology, n (%)* | ||||
| Epithelioid | 6061 (76.2) | 368 (88) | 6429 (76.8) | <0.001* |
| Sarcomatoid | 1149 (14.5) | 18 (4.3) | 1167 (13.9) | |
| Biphasic | 739 (9.3) | 32 (7.7) | 771 (9.2) | |
| Unknown | 3590 | 211 | 3801 | |
| Side, n (%)* | ||||
| Left | 4499 (40.4) | – | – | |
| Right | 6631 (59.6) | – | – | |
| Unknown | 409 | – | – | |
| Stage (TNM), n (%)* | ||||
| I | 2840 (37.2) | – | – | |
| II | 918 (12) | – | – | |
| III | 1971 (25.8) | – | – | |
| IV | 1897 (24.9) | – | – | |
| Unknown | 3913 | – | – | |
| Stage (EOD), n (%)* | ||||
| 1. In situ | – | 0 | – | |
| 2. Local disease | – | 190 (40.8) | – | |
| 3. Contiguous/invasive | – | 123 (26.4) | – | |
| 4. Regional lymph nodes | – | 22 (4.7) | – | |
| 5. Regional progression | – | 12 (2.6) | – | |
| 6. Distant progression | – | 119 (25.5) | – | |
| Unknown | – | 163 | – | |
| Metastases, n (%)† | 610 (10.6) | 54 (18.6) | 664 (11) | <0.001 |
| Multiple metastatic sites | 149 (2.6) | 11 (3.8) | 160 (2.6) | 0.021 |
| Most common metastatic sites, n (%)† | ||||
| Lung | 163 (2.8) | 7 (2.4) | 170 (2.8) | |
| Lymph node | 159 (2.8) | 11 (3.8) | 170 (2.8) | |
| Bone | 135 (2.3) | – | 135 (2.2) | |
| Liver | 73 (1.3) | 13 (4.5) | 86 (1.4) | |
| Peritoneum | 79 (1.4) | 5 (1.7) | 84 (1.4) | |
| Soft tissue | 59 (1) | 3 (1) | 62 (1) | |
| Adrenal glands | 52 (0.9) | 1 (0.3) | 53 (0.9) | |
| Pleura | 12 (0.2) | 15 (5.2) | 27 (0.4) | |
| Cutaneous | 12 (0.2) | – | 12 (0.2) | |
| Brain | 15 (0.3) | – | 15 (0.2) | |
*Percentage and p value based on known cases.
†Metastases were registered nationwide from 2008 onwards; percentages based on 6038 cases (MPM n=5757, MPeM n=291).
EOD, Extent of Disease classification; MPeM, malignant peritoneal mesothelioma; MPM, malignant pleural mesothelioma; TNM, tumour, node, metastases classification.