NDE, NIE, TE and proportion mediated for persistent asthma compared with never by socioeconomic circumstance (N=7487)
| Blocks of mediators | Effects | OR | 95% CI | Proportion mediated % | 95% CI |
| Perinatal characteristics | NDE | 1.43 | 0.72 to 2.84 | 37.5 | 30.6 to 43.3 |
| NIE | 1.18 | 0.98 to 1.42 | |||
| TE | 1.70 | 1.20 to 2.40 | |||
| +Home environment at 3 years | NDE | 1.26 | 0.63 to 2.50 | 61.2 | 56.0 to 65.4 |
| NIE | 1.32 | 1.03 to 1.70 | |||
| TE | 1.70 | 1.20 to 2.40 | |||
| +Exposure to infection at 3 years | NDE | 1.29 | 0.64 to 2.63 | 56.1 | 50.2 to 60.9 |
| NIE | 1.29 | 1.00 to 1.66 | |||
| TE | 1.70 | 1.20 to 2.40 | |||
| +Neighbourhood characteristics at 3 years | NDE | 1.27 | 0.62 to 2.63 | 58.9 | 52.9 to 63.7 |
| NIE | 1.31 | 1.04 to 1.65 | |||
| TE | 1.70 | 1.20 to 2.40 |
NDE, natural direct effect; NIE, natural indirect effect; TE, total effect.