Table 1

Baseline characteristics

CRP <150 mg/LCRP ≥150 mg/LTotal overall
(n=479)
Lenzilumab
(n=168)
Placebo
(n=183)
CRP total
(n=351)
Lenzilumab
(n=53)
Placebo
(n=46)
CRP total
(n=99)
Gender
 Male (%)106 (63)115 (63)221 (63)38 (72)35 (76)73 (74)311 (65)
Age
 Mean (SD)60.9 (13.7)60.4 (14.3)60.6 (13.4)60.8 (13.7)61.1 (14.1)60.9 (13.7)61 (14)
BMI
 Mean (SD)33.4 (8.8)32.5 (8.2)32.9 (8.5)32.5 (7.7)30.3 (6.2)31.5 (7.1)32.5 (8.2)
 ≥30 Kg/m2 (%)58.357.457.856.641.349.555.1
Race (%)
 American Indian3 (2)0 (0)3 (1)1 (2)0 (0)1 (1)5 (1)
 Asian6 (4)5 (3)11 (3)2 (4)0 (0)2 (2)14 (3)
 Black25 (15)26 (14)51 (15)9 (17)6 (13)15 (15)72 (15)
 White121 (72)134 (73)255 (73)38 (71.7)31 (67)69 (70)347 (72)
 Multiple0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)
 Other12 (7)18 (10)30 (9)3 (6)9 (20)12 (12)46 (9)
Ethnicity (%)
 Hispanic or Latino48 (29)74 (40)122 (36)25 (47)21 (46)46 (47)185 (39)
 Not Hispanic or Latino119 (71)108 (59)227 (65)27 (51)23 (50)50 (51)290 (60)
Supplemental oxygen (%)
 Room air
 (Clinical ordinal score=5)
13 (8)10 (6)23 (7)2 (4)2 (4)4 (4)41 (9)
 Low-flow oxygen
 (Clinical ordinal score=4)
90 (54)93 (51)183 (52)26 (49)23 (50)49 (50)242 (50)
 High flow oxygen or NPPV
 (Clinical ordinal score=3)
65 (39)80 (44)145 (41)25 (47)21 (46)46 (47)197 (41)
CRP (mg/L)
 Mean (SD)62.8 (39.8)67.1 (38.4)65.1 (39.1)219 (56.6)210 (53.4)215 (55.0)98.0 (76.0)
 Median58.864.061.120420020179.0
 IQR(27.7–92.0)(34.9–98.7)(32.2–96.8)(185-238)(168-226)(175-232)(41.0–137.1)
Concomitant medications (%)
 Corticosteroids only31 (18)44 (24)75 (21)17 (32)8 (18)25 (26)118 (25)
 Remdesivir only5 (3)6 (3)11 (3)1 (2)2 (4)3 (1)16 (3)
 Corticosteroids and remdesivir127 (75)132 (71)259 (73)33 (62)33 (73)66 (67)331 (69)
Co-morbidity (%)
 Hypertension106 (63)131 (72)237 (68)26 (49)25 (54)51 (52)314 (66)
 Congestive heart failure24 (14)15 (8)39 (11)7 (13)7 (15)14 (14)55 (12)
 Coronary artery disease24 (14)23 (13)47 (13)10 (19)6 (13)16 (16)64 (14)
 Diabetes86 (51)103 (56)189 (54)26 (49)24 (52)50 (51)158 (53)
 Chronic liver disease8 (5)11 (6)19 (5)2 (4)3 (7)5 (5)17 (5)
 Chronic kidney disease26 (16)25 (14)51 (15)8 (15)6 (13)14 (14)67 (14)
 Asthma23 (14)10 (6)33 (9)9 (17)6 (13)15 (15)52 (11)
 Interstitial lung disease3 (2)0 (0)3 (1)1 (2)1 (1.0)2 (0)
 COPD14 (8)15 (8)29 (8)4 (7.5)1 (2)5 (5)36 (7)
  • BMI, body mass index; CRP, C reactive protein.