Race-specific and gender-specific HRs (95% CIs) of SCD according to quintiles of FEV1*
| Whites | Blacks | |||||||||||
| Quintile 1 (lowest) | Quintile 2 | Quintile 3 | Quintile 4 | Quintile 5 (highest) | P for trend† | Quintile 1 (lowest) | Quintile 2 | Quintile 3 | Quintile 4 | Quintile 5 (highest) | P for trend† | |
| Males, n | 1048 | 1049 | 1049 | 1049 | 1048 | 293 | 294 | 293 | 294 | 293 | ||
| Range of FEV1 (mean) | 0.47–2.82 (2.32) | 2.82–3.26 (3.05) | 3.26–3.61 (3.44) | 3.61–3.99 (3.79) | 3.99–5.91 (4.38) | 0.71–2.44 (2.03) | 2.44–2.82 (2.65) | 2.82–3.12 (2.98) | 3.13–3.49 (3.29) | 3.49–5.22 (3.83) | ||
| SCD events, n | 86 | 73 | 63 | 52 | 26 | 43 | 26 | 34 | 20 | 18 | ||
| Person-years, 1000s | 18.62 | 21.59 | 22.90 | 23.94 | 24.87 | 4.22 | 5.26 | 5.83 | 6.13 | 6.40 | ||
| IR (per 103 person-years) | 4.67 | 3.34 | 2.79 | 2.17 | 1.05 | 10.19 | 4.94 | 5.83 | 3.26 | 2.81 | ||
| IRR | 4.41 (2.81 to 7.12) | 3.24 (2.05 to 5.28) | 2.63 (1.64 to 4.33) | 2.08 (1.27 to 3.46) | 1 | 3.62 (2.05 to 6.68) | 1.76 (0.93 to 3.40) | 2.07 (1.14 to 3.90) | 1.16 (0.58 to 2.33) | 1 | ||
| HR (95% CI) | 2.62 (1.62 to 4.26) | 2.05 (1.27 to 3.30) | 1.90 (1.18 to 3.04) | 1.69 (1.05 to 2.72) | 1 | <0.001 | 2.07 (1.05 to 4.11) | 1.20 (0.61 to 2.37) | 1.63 (0.87 to 3.05) | 1.04 (0.53 to 2.05) | 1 | 0.02 |
| Females, n | 1151 | 1152 | 1152 | 1152 | 1152 | 449 | 449 | 449 | 449 | 449 | ||
| Range of FEV1 (mean) | 0.34–2.10 (1.76) | 2.10–2.39 (2.25) | 2.39–2.63 (2.51) | 2.63–2.91 (2.76) | 2.91–4.21 (3.16) | 0.43–1.81 (1.54) | 1.81–2.08 (1.95) | 2.08–2.31 (2.19) | 2.31–2.56 (2.43) | 2.56–3.74 (2.81) | ||
| SCD events, n | 57 | 28 | 20 | 17 | 12 | 37 | 38 | 31 | 16 | 10 | ||
| Person-years, 1000s | 23.16 | 26.14 | 26.98 | 27.60 | 27.98 | 8.07 | 9.11 | 9.46 | 10.13 | 10.49 | ||
| IR (per 103 person-years) | 2.46 | 1.07 | 0.74 | 0.62 | 0.43 | 4.58 | 4.17 | 3.28 | 1.58 | 0.95 | ||
| IRR | 5.74 (3.05 to 11.75) | 2.50 (1.23 to 5.39) | 1.73 (0.80 to 3.88) | 1.44 (0.65 to 3.30) | 1 | 4.81 (2.35 to 10.85) | 4.38 (2.14 to 9.85) | 3.44 (1.64 to 7.86) | 1.66 (0.71 to 4.09) | 1 | ||
| HR (95% CI) | 1.80 (1.03 to 3.15) | 1.16 (0.57 to 2.34) | 0.92 (0.44 to 1.93) | 0.99 (0.47 to 2.10) | 1 | 0.003 | 2.62 (1.21 to 5.65) | 3.10 (1.47 to 6.55) | 2.81 (1.32 to 5.98) | 1.45 (0.62 to 3.37) | 1 | 0.002 |
*Adjusted for age (continuous), education level, body mass index, systolic blood pressure, smoking status, hypertension, diabetes mellitus, history of heart failure, low-density lipoprotein cholesterol, fasting blood glucose, fibrinogen level, albumin level, von Willebrand factor and QTc duration.
†Linear test across median values of FEV1 quintiles.
IR, incidence rate; IRR, incidence rate ratio; SCD, sudden cardiac death.