Table 4

Race-specific and gender-specific HRs (95% CIs) of SCD according to quintiles of FEV1*

WhitesBlacks
Quintile 1 (lowest)Quintile 2Quintile 3Quintile 4Quintile 5 (highest)P for trend†Quintile 1 (lowest)Quintile 2Quintile 3Quintile 4Quintile 5 (highest)P for trend†
Males, n10481049104910491048293294293294293
Range of FEV1 (mean)0.47–2.82 (2.32)2.82–3.26 (3.05)3.26–3.61 (3.44)3.61–3.99 (3.79)3.99–5.91 (4.38)0.71–2.44 (2.03)2.44–2.82 (2.65)2.82–3.12 (2.98)3.13–3.49 (3.29)3.49–5.22 (3.83)
SCD events, n86736352264326342018
Person-years, 1000s18.6221.5922.9023.9424.874.225.265.836.136.40
IR (per 103 person-years)4.673.342.792.171.0510.194.945.833.262.81
IRR4.41 (2.81 to 7.12)3.24 (2.05 to 5.28)2.63 (1.64 to 4.33)2.08 (1.27 to 3.46)13.62 (2.05 to 6.68)1.76 (0.93 to 3.40)2.07 (1.14 to 3.90)1.16 (0.58 to 2.33)1
HR (95% CI)2.62 (1.62 to 4.26)2.05 (1.27 to 3.30)1.90 (1.18 to 3.04)1.69 (1.05 to 2.72)1<0.0012.07 (1.05 to 4.11)1.20 (0.61 to 2.37)1.63 (0.87 to 3.05)1.04 (0.53 to 2.05)10.02
Females, n11511152115211521152449449449449449
Range of FEV1 (mean)0.34–2.10 (1.76)2.10–2.39 (2.25)2.39–2.63 (2.51)2.63–2.91 (2.76)2.91–4.21 (3.16)0.43–1.81 (1.54)1.81–2.08 (1.95)2.08–2.31 (2.19)2.31–2.56 (2.43)2.56–3.74 (2.81)
SCD events, n57282017123738311610
Person-years, 1000s23.1626.1426.9827.6027.988.079.119.4610.1310.49
IR (per 103 person-years)2.461.070.740.620.434.584.173.281.580.95
IRR5.74 (3.05 to 11.75)2.50 (1.23 to 5.39)1.73 (0.80 to 3.88)1.44 (0.65 to 3.30)14.81 (2.35 to 10.85)4.38 (2.14 to 9.85)3.44 (1.64 to 7.86)1.66 (0.71 to 4.09)1
HR (95% CI)1.80 (1.03 to 3.15)1.16 (0.57 to 2.34)0.92 (0.44 to 1.93)0.99 (0.47 to 2.10)10.0032.62 (1.21 to 5.65)3.10 (1.47 to 6.55)2.81 (1.32 to 5.98)1.45 (0.62 to 3.37)10.002
  • *Adjusted for age (continuous), education level, body mass index, systolic blood pressure, smoking status, hypertension, diabetes mellitus, history of heart failure, low-density lipoprotein cholesterol, fasting blood glucose, fibrinogen level, albumin level, von Willebrand factor and QTc duration.

  • †Linear test across median values of FEV1 quintiles.

  • IR, incidence rate; IRR, incidence rate ratio; SCD, sudden cardiac death.