Table 2

HRs (95% CIs) of SCD according to quintiles of FEV1 and FVC*

Quintile 1 (lowest)Quintile 2Quintile 3Quintile 4Quintile 5 (highest)P for trend†
FEV1
N29412942294229422941
Range of FEV1 (mean)0.34–2.17 (1.81)2.17–2.56 (2.37)2.56–2.93 (2.74)2.93–3.47 (3.18)3.47–5.91 (3.96)
SCD events, n202124118141121
Person-years, 1000s56.6963.6265.4665.3467.58
IR (per 103 person-years)3.561.951.802.161.79
IRR1.99 (1.58 to 2.51)1.09 (0.84 to 1.41)1.01 (0.77 to 1.31)1.21 (0.94 to 1.55)1.00
HR (95% CI)2.72 (2.03 to 3.64)1.59 (1.19 to 2.12)1.35 (1.03 to 1.78)1.20 (0.93 to 1.54)1.00<0.001
FVC
N29412942294229422941
Range of FVC (mean)0.77–2.94 (2.53)2.94–3.43 (3.19)3.43–3.94 (3.68)3.94–4.66 (4.28)4.66–8.25 (5.30)
SCD events, n198102132145129
Person-years, 1000s58.5764.6165.1863.6066.73
IR (per 103 person-years)3.381.582.032.281.93
IRR1.75 (1.39 to 2.20)0.82 (0.62 to 1.07)1.05 (0.82 to 1.35)1.18 (0.92 to 1.51)1.00
HR (95% CI)2.59 (1.87 to 3.58)1.32 (0.97 to 1.79)1.33 (1.02 to 1.73)1.14 (0.82 to 1.34)1.00<0.001
  • *Adjusted for age (continuous), race, gender, education level, body mass index, systolic blood pressure, smoking status, hypertension, diabetes mellitus, history of heart failure, low-density lipoprotein cholesterol, fasting blood glucose, fibrinogen level, albumin level, von Willebrand factor and QTc duration.

  • †Linear test across median values of FEV1 quintiles.

  • ‡Linear test across median values of FVC quintiles.

  • IR, incidence rate; IRR, incidence rate ratio;SCD, sudden cardiac death.