HRs (95% CIs) of SCD according to quintiles of FEV1 and FVC*
| Quintile 1 (lowest) | Quintile 2 | Quintile 3 | Quintile 4 | Quintile 5 (highest) | P for trend† | |
| FEV1 | ||||||
| N | 2941 | 2942 | 2942 | 2942 | 2941 | |
| Range of FEV1 (mean) | 0.34–2.17 (1.81) | 2.17–2.56 (2.37) | 2.56–2.93 (2.74) | 2.93–3.47 (3.18) | 3.47–5.91 (3.96) | |
| SCD events, n | 202 | 124 | 118 | 141 | 121 | |
| Person-years, 1000s | 56.69 | 63.62 | 65.46 | 65.34 | 67.58 | |
| IR (per 103 person-years) | 3.56 | 1.95 | 1.80 | 2.16 | 1.79 | |
| IRR | 1.99 (1.58 to 2.51) | 1.09 (0.84 to 1.41) | 1.01 (0.77 to 1.31) | 1.21 (0.94 to 1.55) | 1.00 | |
| HR (95% CI) | 2.72 (2.03 to 3.64) | 1.59 (1.19 to 2.12) | 1.35 (1.03 to 1.78) | 1.20 (0.93 to 1.54) | 1.00 | <0.001 |
| FVC | ||||||
| N | 2941 | 2942 | 2942 | 2942 | 2941 | |
| Range of FVC (mean) | 0.77–2.94 (2.53) | 2.94–3.43 (3.19) | 3.43–3.94 (3.68) | 3.94–4.66 (4.28) | 4.66–8.25 (5.30) | |
| SCD events, n | 198 | 102 | 132 | 145 | 129 | |
| Person-years, 1000s | 58.57 | 64.61 | 65.18 | 63.60 | 66.73 | |
| IR (per 103 person-years) | 3.38 | 1.58 | 2.03 | 2.28 | 1.93 | |
| IRR | 1.75 (1.39 to 2.20) | 0.82 (0.62 to 1.07) | 1.05 (0.82 to 1.35) | 1.18 (0.92 to 1.51) | 1.00 | |
| HR (95% CI) | 2.59 (1.87 to 3.58) | 1.32 (0.97 to 1.79) | 1.33 (1.02 to 1.73) | 1.14 (0.82 to 1.34) | 1.00 | <0.001 |
*Adjusted for age (continuous), race, gender, education level, body mass index, systolic blood pressure, smoking status, hypertension, diabetes mellitus, history of heart failure, low-density lipoprotein cholesterol, fasting blood glucose, fibrinogen level, albumin level, von Willebrand factor and QTc duration.
†Linear test across median values of FEV1 quintiles.
‡Linear test across median values of FVC quintiles.
IR, incidence rate; IRR, incidence rate ratio;SCD, sudden cardiac death.