Table 3

Incremental prognostic value of the addition of FEV1 or FVC to the basic model for SCD

td-ROC (95% CI)P value*C statistic (95% CI)P value*NRI (95% CI)P value†
Basic model‡0.79 (0.77 to 0.82)0.74 (0.72 to 0.76)
Basic model+FEV1 0.84 (0.82 to 0.86)<0.0010.77 (0.75 to 0.79)<0.00140.7% (32.3% to 49.2%)<0.001
Basic model+FVC0.82 (0.80 to 0.84)<0.0010.76 (0.74 to 0.78)0.00222.7% (14.2% to 31.2%)<0.001
  • *P value compared with basic model.

  • †P value for NRI.

  • ‡Variables included in basic model: age (continuous), race, gender, education level, body mass index, systolic blood pressure, smoking status, hypertension, diabetes mellitus, history of heart failure, low-density lipoprotein cholesterol, fasting blood glucose, fibrinogen level, albumin level, von Willebrand factor and QTc duration.

  • NRI, net reclassification improvement; SCD, sudden cardiac death; td-ROC, time-dependent receiver operating characteristic.