Table 1

Summary of human studies with gene expression profile data in asthma focusing on lncRNAs

	Study	Technology	Sample type	Candidate/identified lncRNAs	Upregulated lncRNAs (n)	Downregulated lncRNAs (n)
T cells
	Tsitsiou et al 32	Microarray	Human CD4⁺ T cells from circulating blood Severe asthma (n=12), healthy subjects (n=8)	AC090517.2	Severe asthma versus healthy: 0	Severe asthma versus healthy: 6
	Tsitsiou et al 32	Microarray	Human CD8⁺ T cells from circulating blood Severe asthma (n=12), healthy subjects (n=8)	MEG3, SNHG3, FBLL1, GHRLOS	Severe asthma versus healthy: 141	Severe asthma versus healthy: 26
	Qi et al 33	Microarray	Human CD4⁺ T cells from circulating blood Asthma (n=5), healthy subjects (n=5)	lnc-NOS2-1, lnc-FAM222B-1	Asthma versus control: 863	Asthma versus control: 1862
	Qiu et al 34	Microarray	Human CD4⁺ T cells from circulating blood Severe asthma (n=52), healthy subjects (n=45)	MALAT1, MEG3, GAS5, NEAT1, DANCR, HULC, FTLP3, KCNA3, CACS7	Severe asthma versus healthy: 112	Severe asthma versus healthy: 113
Blood
	Chen et al 37	Next-generation sequencing	Human whole blood severe asthma (n=3), mild asthma (n=3) healthy subjects (n=3)	RP5-857K21.7, RP11-58A11.2, lnc-TRAP1-1	Mild versus normal: 20 Severe versus normal: 504 Severe versus mild: 50	Mild versus normal: 76 Severe versus normal: 104 Severe versus mild: 93
	Zhu et al 39	Next-generation sequencing	Human whole blood Eosinophilic asthma (n=9 of which n=6 had high IgE and n:3 had low IgE) and control subjects (n=3)	HNRNPU-AS1, RP11-4O1.2, RP5-998N21.4, XLOC_000953, OIP5-AS1, SCARNA10, XLOC_011115	Asthma versus control: 27	Asthma versus control: 14
	Zhu et al 38	Next-generation sequencing	Human whole blood Neutrophilic asthma (n=6), eosinophilic asthma (n=12) and control subjects (n=6)	LNC_000127	Asthma versus control: 117	Asthma versus control: 178
Airways
	Liu et al 40	Microarray	Human airway epithelial brushings Asthma (n=62) and healthy controls (n=43)	AC124067.4, ZNF667AS1, AC005906.2, AL357568.2, AC130650.2, STX18AS1, LINC02363, LINC02145	Asthma versus control: 48	Asthma versus control: 111
	Austin et al 41	Microarray	Human primary ASMCs Non-severe asthma (n=9), severe asthma (n=9) and healthy controls (n=9)	PVT1, LINC00472, RP5-1158E12.3, FKBP1A-SDCBP2	Non-severe versus control: 15 Severe versus control: 13	Non-severe versus control: 6 Severe versus control: 6

A selection of lncRNAs of interest based on the focus of the article or literature is mentioned in the table.
ASMC, airway smooth muscle cell; lncRNA, long non-coding RNA.