Overlaps between previously reported glucocorticoid gene set (GCGS) with the top 5% PC1 and PC3 contributing genes (unsupervised), the top 5% Th2 clinical feature rank correlated genes (supervised) from Severe Asthma Research Program, and target genes of the top 5% PC3 contributing microRNAs (unsupervised) from GSE34466
| GCGS overlap with each test variable | PC1 28.93% | PC3 11.93% | Baseline blood baso | Baseline blood eos | Baseline FeNO | Change FeNO | GSE34466 PC3 | Test variable | GCGS |
| # genes in overlap | 15 598 | 15 592 | 15 531 | 15 542 | 15 544 | 15 556 | 16 040 | No | No |
| 484 | 490 | 553 | 545 | 545 | 526 | 522 | No | Yes | |
| 753 | 759 | 820 | 809 | 807 | 795 | 311 | Yes | No | |
| 95 | 89 | 26 | 34 | 34 | 53 | 57 | Yes | Yes | |
| OR(95% CI) | 4.07 (3.22 to 5.13)* | 3.73 (2.94 to 4.73)* | 0.89(0.60 to 1.33) | 1.20(0.84 to 1.71) | 1.20(0.84 to 1.71) | 1.97 (1.47 to 2.64)* | 5.63 (4.19 to 7.57)* |
The number of overlapping genes, ORs and Fisher exact test 95% CI are indicated.
*Indicates statistical significance.