Table 2
lncRNAs and their possible interaction partners and effects, based on human and animal data
| lncRNAs | Cell type | Proposed interaction partners | Impact on pathway or transcription factor | Proposed effects | Upregulated or downregulated |
| MEG3 | Human CD8+ T cells32 |
| |||
| Human serum45 | Asthma progression45 |
| |||
| Human CD4+ T cells34 | MicroRNA-1734 | RORγT34 | Th17 imbalance34 |
| |
| LNC_000127 | Human whole blood38 | GATA338 | Th2 inflammation38 |
| |
| LNC_00882 | Human ASMCs46 47 | MicroRNA-3169–5 p46
MicroRNA-37147 | Wnt/β-catenin46
Runx348 | Airway remodelling46
Th1/Th2 imbalance48 |
|
| CACS7 | Human ASMCs49 | MicroRNA-2149 | PTEN/AKT49 | Corticosteroid sensitivity49 |
|
| MALAT1 | Human ASMCs50
Human CD4+ T cells51 Rat ASMCs52 53 | MicroRNA-15050
MicroRNA-15551 MicroRNA-261a52 MicroRNA-133a53 | AKT50
CTLA-451 | Airway remodelling50
Th1/Th2 imbalance51 |
|
| TUG1 | Rat ASMCs57
Mice ASMCs58 Human monocytes56 | MicroRNA-590–5 p57
MicroRNA-181b58 MicroRNA-29c56 | NF-κB58 | Airway remodelling57
Inflammation58 Th2 cell differentiation56 |
|
| TCF7 | Human ASMCs78 | TIMMDC178 | AKT81 | Airway remodelling78 |
|
| GAS5 | Rat ASMCs61
Human ASMCs62 Human monocytes63 | MicroRNA-10a61 | BDNF64 | Airway hyper-responsiveness61
Glucocorticoid insensitivity62 Severity63 |
|
| BCYRN1 | Rat ASMCs76 | TRPC176 | Airway remodelling82 |
| |
| PVT1 | Human ASMCs41 | Airway remodelling41 |
| ||
| Rat ASMCs65 | MicroRNA-203a65 | E2F365 | Reaction on α-asarone and airway remodelling65 | ||
| Mice ASMCs and CD4+ T cells66 | MicroRN29c-3p66 | AKT/mToR66 | |||
| Human small airway epithelial cells67 | MicroRNA-14967 | ||||
| NEAT1 | Human leucocytes68
Human plasma11 | MicroRNA-12411 | Exacerbation risk11 |
| |
| ANRIL | Human plasma12 | MicroRNA-125a12 | Exacerbation risk12 |
| |
| AK085865 | Asthma mice model77 | Inflammation77 |
| ||
| PINT | Rat ASMCs69 | MicroRNA-26a-5p69 | PTEN69 | Inflammation69 |
|
| NKILA | Asthma mice model70 | NF-κB70 | M2 macrophage polarisation70 |
| |
| CRNDE | Human PBMCs71 | MicroRNA-33a & MicroRNA-49571 | Exacerbation severity71 |
| |
| n337374 | Asthma mice model72 | Inflammation72 |
| ||
| OIP5-AS1 | BEAS-2B cell line73 | MicroRNA-143–3 p73 | HMGB173 | Inflammation and apoptosis73 |
|
| H19 | Human ASMCs74 | MicroRNA-2174 | AKT74 | Airway remodelling74 |
|
| lncBAZ2B | Human PBMCs75 | BAZ2B75 | M2 macrophage activation75 |
|
ASMC, airway smooth muscle cell; lncRNA, long non-coding RNA; PBMC, peripheral blood mononuclear cell.