Table 2

lncRNAs and their possible interaction partners and effects, based on human and animal data

lncRNAsCell typeProposed interaction partnersImpact on pathway or transcription factorProposed effectsUpregulated or downregulated
MEG3Human CD8+ T cells32 Embedded Image
Human serum45 Asthma progression45 Embedded Image
Human CD4+ T cells34 MicroRNA-1734 RORγT34 Th17 imbalance34 Embedded Image
LNC_000127Human whole blood38 GATA338 Th2 inflammation38 Embedded Image
LNC_00882Human ASMCs46 47 MicroRNA-3169–5 p46
MicroRNA-37147
Wnt/β-catenin46
Runx348
Airway remodelling46
Th1/Th2 imbalance48
Embedded Image
CACS7Human ASMCs49 MicroRNA-2149 PTEN/AKT49 Corticosteroid sensitivity49 Embedded Image
MALAT1Human ASMCs50
Human CD4+ T cells51
Rat ASMCs52 53
MicroRNA-15050
MicroRNA-15551
MicroRNA-261a52
MicroRNA-133a53
AKT50
CTLA-451
Airway remodelling50
Th1/Th2 imbalance51
Embedded Image
TUG1Rat ASMCs57
Mice ASMCs58
Human monocytes56
MicroRNA-590–5 p57
MicroRNA-181b58
MicroRNA-29c56
NF-κB58 Airway remodelling57
Inflammation58
Th2 cell differentiation56
Embedded Image
TCF7Human ASMCs78 TIMMDC178 AKT81 Airway remodelling78 Embedded Image
GAS5Rat ASMCs61
Human ASMCs62
Human monocytes63
MicroRNA-10a61 BDNF64 Airway hyper-responsiveness61
Glucocorticoid insensitivity62
Severity63
Embedded Image
BCYRN1Rat ASMCs76 TRPC176 Airway remodelling82 Embedded Image
PVT1Human ASMCs41 Airway remodelling41 Embedded Image
Rat ASMCs65 MicroRNA-203a65 E2F365 Reaction on α-asarone and airway remodelling65
Mice ASMCs and CD4+ T cells66 MicroRN29c-3p66 AKT/mToR66
Human small airway epithelial cells67 MicroRNA-14967
NEAT1Human leucocytes68
Human plasma11
MicroRNA-12411 Exacerbation risk11 Embedded Image
ANRILHuman plasma12 MicroRNA-125a12 Exacerbation risk12 Embedded Image
AK085865Asthma mice model77 Inflammation77 Embedded Image
PINTRat ASMCs69 MicroRNA-26a-5p69 PTEN69 Inflammation69 Embedded Image
NKILAAsthma mice model70 NF-κB70 M2 macrophage polarisation70 Embedded Image
CRNDEHuman PBMCs71 MicroRNA-33a & MicroRNA-49571 Exacerbation severity71 Embedded Image
n337374Asthma mice model72 Inflammation72 Embedded Image
OIP5-AS1BEAS-2B cell line73 MicroRNA-143–3 p73 HMGB173 Inflammation and apoptosis73 Embedded Image
H19Human ASMCs74 MicroRNA-2174 AKT74 Airway remodelling74 Embedded Image
lncBAZ2BHuman PBMCs75 BAZ2B75 M2 macrophage activation75 Embedded Image
  • ASMC, airway smooth muscle cell; lncRNA, long non-coding RNA; PBMC, peripheral blood mononuclear cell.