Airway epithelium | Alveolar epithelium | ||||
Primary | Cell line | Primary | Cell line | ||
PRRs | TLRs | TLR121 48 90 | TLR148 90 | TLR291 | TLR291 |
TLR221 48 90 | TLR248 90 | TLR392 | TLR392 | ||
TLR321 48 90 | TLR348 90 | TLR491 | TLR491 | ||
TLR421 48 90 | TLR448 90 93 | ||||
TLR521 48 90 | TLR548 90 93 | ||||
TLR621 48 90 | TLR648 90 | ||||
TLR790 | TLR748 | ||||
TLR890 | TLR990 | ||||
TLR948 90 | TLR1090 | ||||
TLR1090 | |||||
TLR coreceptors | CD1490 | CD1491 | |||
MD291 | |||||
NLRs | NOD148 | NOD193 | NOD194 | NOD194 | |
NLRP195 | NOD293 | ||||
NLRP396 | |||||
Lectins | Dectin-197 | Dectin-197 | |||
MINCLE98 | L-SIGN99 | ||||
MINCLE98 | |||||
Nucleic acid sensors | RIG1100 | RIG1101 | RIG192 | RIG192 | |
MDA5101 | MDA5102 | ||||
LGP2101 | |||||
Other | SDC440 | ||||
AMPs and proteins | Defensins | hBD180 | hBD2103 | ||
hBD280 | |||||
Cathelicidins | LL-3780 | LL-3725 | |||
Other | Lactoferrin80 | Hepcidin104 | |||
Hepcidin80 | |||||
Cytokines | Pro-inflammatory | IL-621 44 48 | IL-848 90 93 105 | IL-18106 | IL-6107 |
IL-821 48 80 | IL-32108 | IL-891 105 107 | |||
IL-32108 | IL-17107 | ||||
IL-32108 | |||||
IFN-γ107 | |||||
TNF-α107 | |||||
Anti-inflammatory | IL-1044 | IL-10105 | IL-1RA107 | ||
IL-2244 | IL-4107 | ||||
IL-9107 | |||||
IL-10105 | |||||
IL-13107 | |||||
Chemotactic | CCL2021 | CCL291 107 | |||
CXCL1021 | CCL3107 | ||||
GM-CSF21 80 | CCL4107 | ||||
CCL5107 | |||||
CXCL1092 107 | |||||
GM-CSF107 | |||||
G-CSF107 |
PRRs expressed by human lung epithelial cells (blue). AMPs and cytokines expressed or produced by human lung epithelium on mycobacterial stimulation (green).
GM-CSF, Granulocyte-Macrophage Colony Stimulating Factor; IFN-γ, interferon gamma; IL, interleukin; NK, Natural Killer; NLRs, NOD-like receptors; SDC4, syndecan 4; TLR, Toll-like receptor; TNF-α, Tumor Necrosis Factor - Alpha.