Associations between breathlessness in parents and their offspring
| Exposure variable | Association with offspring breathlessness, OR (95% CI) | ||
| Crude | Adjusted for parental factors only | Adjusted for both parental and offspring factors | |
| Parental breathlessness, main analysis | 1.7 (1.3 to 2.2) n=2476 | 1.8 (1.1 to 2.7) n=1143 | 1.8 (1.1 to 2.9) n=1040 |
| Parental breathlessness, defined without concurrent wheeze | 1.6 (1.1 to 2.5) n=2476 | 1.8 (0.9 to 3.4) n=1058 | 1.5 (0.7 to 3.2) n=961 |
Association between parental and offspring breathlessness, analysed using logistic regression, accounting for clustering within centres and between siblings. Estimates are expressed as ORs with 95% CIs. Adjustment factors in parents and offspring were age, sex, Body Mass Index category, asthma, current smoking, pack-years of smoking, depression (parents only), highest education, airflow limitation (FEV1/FVC<0.7, parents only) and FVC (parents only). See table 1 for abbreviations.