Parameter* | Classification of change | Improvement | No change | Deterioration |
BMI | Change≥1.46 kg/m2 | 106 (36.2%) | 168 (57.3%) | 19 (6.5.%) |
2.79 (2.15 to 4.34) | 0.20 (−0.30 to 0.80) | −2.04 (−2.77 to −1.52) | ||
SGRQ | Change≥4 units | 158 (53.2%) | 127 (42.8%) | 12 (4.04%) |
−18.17 (−26.53 to 9.91) | 0 (−1.84 to 0) | 17.01 (10.80 to 19.81) | ||
6 min walk test distance | Change≥26 m | 142 (53.6%) | 72 (27.2%) | 51 (19.3%) |
75.28 (49.95 to 102.09) | 3.48 (−8.23 to 12.85) | (−85.96 to −41.23) | ||
6 min walk test desaturation (SpO2 less 92% at end of walk) | Change ‘yes’ or ‘no’ | 14 (5.26%) | 248 (93.2%) | 4 (1.50%) |
Presence of monthly symptoms | Change between present/absent monthly symptoms | 125 (41.5%) | 166 (55.2%) | 10 (3.3%) |
FEV1 (L)† | Change≥100 mL | 88 (35.8%) | 85 (34.6%) | 73 (29.7%) |
0.21 (0.15 to 0.31) | 0 (−0.04 to 0.06) | −0.18 (−0.31 to − 0.14) | ||
FVC (L)† | Change≥100 mL | 126 (51.2%) | 68 (27.6%) | 52 (21.1%) |
0.25 (0.17 to 0.42) | 0 (−0.03 to 0.05) | −0.25 (−0.34 to −0.15) | ||
Unscheduled visit to healthcare for respiratory condition | Change≥1 visit | 46 (15.4%) | 246 (82.3%) | 7 (2.3%) |
−1 (−1 to −1) | 0 (0 to 0) | 2 (2 to 2) |
Measure between baseline visit and last visit at 3 years (n=309).
*All continuous variable normalised to time (1095 days since baseline measurements).
†Matched postbronchodilator spirometry to ATS standards, n=246.
BMI, body mass index; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity.