Interaction between log10endotoxin and GRS in relation to FEV1/FVC
| Exposure | n | FEV1/FVC | ||||
| Intercept* | log10endotoxin effect† | GRS effect‡ | GRS×log10endotoxin interaction§ | Pinteraction¶ | ||
| Endotoxin | ||||||
| log10endotoxin | 2208 | 0.754 | −0.004 | −0.004 | −0.001 | 0.248 |
*The intercept is the FEV1/FVC value for a subject calculated at the mean value for all continuous variables in the model (GRS, log10endotoxin, age, age2, height, height2, pack-years and 10 principal components) and at the reference category for all categorical covariates (ie, never smoker, non-asthmatic, summer season of collection, female and residing at Iowa).
†The effect of log10endotoxin is the difference in FEV1/FVC per unit increase in log10endotoxin, calculated at the mean value for all continuous variables (GRS, age, age2, height, height2, pack-years and 10 principal components) and at the reference category for all categorical covariates (ie, never smoker, non-asthmatic, summer season of collection, female and residing at Iowa).
‡The effect for the GRS is the slope for the GRS, which is interpretable as the difference in FEV1/FVC per unit increase in the GRS, calculated at the mean value for all continuous variables (log10endotoxin, age, age2, height, height2, pack-years and 10 principal components) and at the reference category for all categorical covariates (ie, never smoker, non-asthmatic, summer season of collection, female and residing at Iowa).
§The interaction effect between the GRS and log10endotoxin is the difference in the effect estimate for the GRS per unit increase in log10endotoxin.
¶The p value for interaction between the GRS and log10endotoxin.
GRS, Genetic Risk Score.