Table 4

Overlaps between gene sets from the 19-subject Severe Asthma Research Program study: the top 5% PC1 and PC3 contributing genes (unsupervised), and the top 5% Th2 phenotypes rank correlated genes (supervised)

Top 5% gene overlapsPC3 11.93%Baseline blood basoBaseline blood eosBaseline FeNOChange FeNO
PC1 28.93%510623623109# gene overlap
70.28*1.54*0.840.52*3.06*OR
(59.02 to 83.70)*(1.18 to 2.01)*(0.60 to 1.18)(0.34 to 0.79)*(2.47 to 3.79)*(95% CI)
PC3 11.93%47743682
1.121.90*0.842.14*
(0.83 to 1.52)(1.48 to 2.44)*(0.60 to 1.18)(1.69 to 2.72)*
Baseline
blood baso
73539
1.88*1.300.20*
(1.46 to 2.41)*(0.97 to 1.73)(0.10 to 0.38)*
Baseline blood eos8410
2.24*0.22*
(1.77 to 2.84)*(0.12 to 0.41)*
Change
FeNO
180
6.29*
(5.24 to 7.54)*
  • The number of overlapping genes, ORs and Fisher exact test 95% CI are indicated.

  • *indicates statistical significance.