Top 10% significant gene ontology (GO) clusters and their keywords for the top 5% PC1 and PC3 negative and positive contributing genes from the 19-subject Severe Asthma Research Program study
| PC1 | PC3 | |
| # genes top 5% negative (N) | 378 | 371 |
| # GO clusters (N) | 93 | 70 |
| # genes top 5% positive (P) | 470 | 477 |
| # GO clusters (P) | 90 | 117 |
| Top 10% GO cluster order (N) | Score | Keyword | Score | Keyword |
| 1 | 13.92 | lysosome | 13.67 | ribosome, RNA processing |
| 2 | 12.64 | cell adhesion | 6.88 | lysosome |
| 3 | 9.14 | glycosylation | 5.24 | cell-cell adhesion |
| 4 | 5.19 | host-virus interaction | 2.59 | phosphatidylinositol binding, retromer |
| 5 | 3.93 | chaperone, endoplasmic reticulum | 2.56 | innate immunity |
| 6 | 3.72 | cell adhesion | 2.33 | annexin |
| 7 | 3.66 | ATP-binding | 2.23 | NAD, oxidation-reduction |
| 8 | 3.45 | actin-binding, spectrin | ||
| 9 | 3.36 | antigen processing and presentation, asthma, MHC class II |
| Top 10% GO cluster order (P) | Score | Keyword | Score | Keyword |
| 1 | 25.36 | immunity | 16.50 | cell-cell adhesion |
| 2 | 12.41 | response to virus | 11.54 | innate immunity |
| 3 | 7.68 | ribosome, RNA processing | 8.19 | cell membrane |
| 4 | 3.66 | antigen processing and presentation, MHC class I | 4.73 | virus receptor activity |
| 5 | 2.88 | infection | 3.77 | antigen processing and presentation, asthma, interferon, MHC class I, MHC class II |
| 6 | 2.75 | NF-kappa B signalling | 3.74 | ATP-binding |
| 7 | 2.42 | interferon | 3.65 | GTP-binding |
| 8 | 2.39 | chemotaxis, cytokine | 3.65 | chemotaxis, cytokine |
| 9 | 2.12 | Ig-binding | 3.55 | SH3 domain |
| 10 | 3.53 | glycosylation, transmembrane | ||
| 11 | 3.28 | lysosome |