Table 2

Effect of MPR on FEV1 and BMI

MPROutcomeRegression coefficient ±SEP value
FEV1
Overall MPRFEV1 change from baseline (quarterly)1.29±0.880.14
Overall MPRFEV1 change from baseline at 60 m5.82±2.780.036*
Annual MPRFEV1 change from previous year1.06±0.380.006*
BMI
Overall MPRBMI change from baseline (quarterly)−0.48±0.210.027*
Overall MPRBMI change from baseline at 60 m1.01±0.750.178
Annual MPRBMI change from previous year0.07±0.080.36
  • Overall MPR=MPR for the whole duration of treatment (up to 5 years). Annual MPR=MPR for each year of treatment. Regression coefficient represents the mean change in percent predicted FEV1 for each MPR increase of 0.1 (10%) as calculated using generalised estimating equations.

  • BMI, body mass index; MPR, medicine possession ratio.