Table 2

OR for individual symptoms in current smokers versus non-smokers

N
(non-smokers/smokers)
Standard users
2 221 088
(220 135/1 819 505)
COVID-19
self-reported
157 406
(18 845/117 848)
SARS-CoV-2
tested –
16 759
(1418/13 902)
SARS-CoV-2
tested +
7123
(472/5908)
SymptomOR (95% CI)P valueOR (95% CI)P valueOR (95% CI)P valueOR (95% CI)P value
Abdominal pain 1.35 (1.33 to 1.38) 8.35×10–198 1.43 (1.37 to 1.50) 7.21×10–57 1.33 (1.13 to 1.56) 6.94×10–4 1.43 (1.15 to 1.77) 1.07×10–3
Chest pain 1.16 (1.14 to 1.18) 1.42×10–63 1.10 (1.06 to 1.14) 4.04×10–6 1.06 (0.92 to 1.23)4.06×10–1 1.31 (1.07 to 1.62)1.08×10–2
Delirium 1.22 (1.20 to 1.25) 2.12×10–93 1.26 (1.20 to 1.31) 1.08×10–23 1.60 (1.34 to 1.89) 8.09×10–8 1.83 (1.47 to 2.27) 4.38×10–8
Diarrhoea 1.31 (1.29 to 1.33) 3.94×10–210 1.28 (1.23 to 1.34) 5.59×10–29 1.31 (1.12 to 1.53) 5.55×10–4 1.14 (0.92 to 1.40)2.34×10–1
Fatigue 1.06 (1.05 to 1.08) 1.75×10–15 0.94 (0.90 to 0.99)1.40×10–2 1.00 (0.84 to 1.18)9.55×10–1 0.78 (0.57 to 1.10)1.46×10–1
Fever1.01 (0.98 to 1.03)6.37×10–1 1.01 (0.96 to 1.06)8.42×10–1 0.87 (0.74 to 1.02)8.79×10–2 0.86 (0.70 to 1.06)1.54×10–1
Headache 1.10 (1.08 to 1.12) 1.91×10–25 1.30 (1.24 to 1.36) 2.77×10–25 1.03 (0.87 to 1.22)7.23×10–1 1.08 (0.83 to 1.41)5.89×10–1
Hoarse voice 1.06 (1.04 to 1.08) 8.38×10–8 1.06 (1.01 to 1.10)1.04×10–2 0.95 (0.81 to 1.12)5.48×10–1 1.19 (0.97 to 1.46)1.02×10–1
Anosmia 1.07 (1.05 to 1.09) 6.98×10–11 0.88 (0.85 to 0.92) 4.82×10–9 1.18 (0.99 to 1.39)5.55×10–2 0.93 (0.74 to 1.17)5.32×10–1
Persistent cough 1.18 (1.16 to 1.20) 8.28×10–90 0.99 (0.95 to 1.03)5.31×10–1 0.88 (0.76 to 1.01)7.27×10–2 0.73 (0.59 to 0.90)2.96×10–3
Shortness of breath 1.16 (1.14 to 1.18) 3.34×10–71 1.09 (1.05 to 1.14) 1.40×10–5 1.11 (0.96 to 1.29)1.40×10–1 1.35 (1.09 to 1.68)6.53×10–3
Skipped meals 1.76 (1.73 to 1.79) p<2.23e-308 1.52 (1.46 to 1.59) 4.78×10–88 1.46 (1.26 to 1.70) 6.92×10–7 1.31 (1.06 to 1.61)1.15×10–2
Sore throat 0.93 (0.91 to 0.95) 2.04×10–14 1.17 (1.12 to 1.23) 2.00×10–11 0.90 (0.77 to 1.06)2.12×10–1 1.32 (1.06 to 1.65)1.30×10–2
Unusual muscle pains 1.47 (1.43 to 1.52) 2.41×10–151 1.46 (1.37 to 1.55) 8.90×10–30 1.24 (1.02 to 1.50)3.18×10–2 1.19 (0.94 to 1.51)1.40×10–1
  • For each test group, the table reports the OR (95% CI) and p value of the association between smoking status and individual COVID-19 symptoms, adjusted for age, sex and BMI. An OR >1 reflects an increased likelihood of this symptom being reported in current smokers. Associations passing Bonferroni correction for multiple testing (p<1.14×10−3) are highlighted in bold.