Table 2

Secondary outcomes

Secondary outcomesInterventionStandard of careP value
PFIT-s at ICU discharge9.4
(8.0 to 10.8) n=37
9.6
(8.3 to 10.9) n=42
0.77*
Rectus muscle diameter at ICU discharge (mean difference from baseline (cm))−11 (−17 to −6) % n=57−13 (−19 to −7) % n=540.64
MRC score at ICU discharge42.4
(39.2 to 45.6)
39.4
(36.5 to 42.4)
0.13
Nitrogen balance (gN/m2/day)−2.7
(−3.1 to −2.4)
n=852 days of 75 patients
−3.4
(−3.7 to −3.0)
n (days)=759 days of 75 patients
0.004
Ventilator-free days at D289.3
(6.5 to 12.0) n=75
11.0
(8.2 to 13.8) n=75
0.33
Number of untoward dialysis interruptions/days of rehabilitation during dialysis0/170/41N/A
Numbers of ICP elevations/days with ICP measured1.5 (0.2 to 2.9)
(n=4 patients, 15 ICP days)
0 (n=3 patients, 15 ICP days) 0.018*
  • Unless stated otherwise, data presented as means (95% CIs) and p values are from t-test.

  • PFIT-s ranging from 0 to 12 points with lower scores meaning higher degree of disability, see also online supplemental figure 1 and online supplemental table 4 in online supplemental appendix 1.

  • MRC score ranging from 0 to 60 points with higher scores meaning increasing muscle power.

  • Bold values indicate statistical significance.

  • *Wilcoxon test.

  • ICP, intracranial pressure; ICU, intensive care unit; MRC, Medical Research Council; PFIT-s, Four-item Physical Fitness in Intensive Care Test.