Exposure | n | FEV_{1}/FVC | ||||

Intercept* | log_{10}endotoxin effect† | GRS effect‡ | GRS×log_{10}endotoxin interaction§ | P_{interaction}¶ | ||

Endotoxin | ||||||

log_{10}endotoxin | 2208 | 0.754 | −0.004 | −0.004 | −0.001 | 0.248 |

*The intercept is the FEV

_{1}/FVC value for a subject calculated at the mean value for all continuous variables in the model (GRS, log_{10}endotoxin, age, age^{2}, height, height^{2}, pack-years and 10 principal components) and at the reference category for all categorical covariates (ie, never smoker, non-asthmatic, summer season of collection, female and residing at Iowa).†The effect of log

_{10}endotoxin is the difference in FEV_{1}/FVC per unit increase in log_{10}endotoxin, calculated at the mean value for all continuous variables (GRS, age, age^{2}, height, height^{2}, pack-years and 10 principal components) and at the reference category for all categorical covariates (ie, never smoker, non-asthmatic, summer season of collection, female and residing at Iowa).‡The effect for the GRS is the slope for the GRS, which is interpretable as the difference in FEV

_{1}/FVC per unit increase in the GRS, calculated at the mean value for all continuous variables (log_{10}endotoxin, age, age^{2}, height, height^{2}, pack-years and 10 principal components) and at the reference category for all categorical covariates (ie, never smoker, non-asthmatic, summer season of collection, female and residing at Iowa).§The interaction effect between the GRS and log

_{10}endotoxin is the difference in the effect estimate for the GRS per unit increase in log_{10}endotoxin.¶The p value for interaction between the GRS and log

_{10}endotoxin.GRS, Genetic Risk Score.