Table 2

Most significant differentially methylated positions (DMPs) for airway obstruction in people living with HIV

DMP
TraitProbeChr**GeneRelation to IslandBetaSEP valueFDR
FEV1/FVC ratio <70%cg011756052 HK2 Open Sea−0.003450.0324.42×10−09 1.16×10−03
cg208684105 HBEGF South Shore0.002310.0373.71×10−10 2.26×10−04
cg273859406 TAPBP Island0.135920.0237.47×10−09 1.47×10−03
cg132099907 MAD1L1 Open Sea−0.220580.0389.65×10−09 1.52×10−03
cg1363259519UnknownOpen Sea0.180690.3205.74×10−10 2.26×10−04
FEV1/FVC ratio <LLNcg130713061 GPR153 Island−0.002150.0295.72×10−11 1.50×10−05
cg234556292UnknownOpen Sea−0.409230.0631.03×10−10 2.04×10−05
cg152883103 VGLL4 South Shelf−0.025610.0471.40×10−13 5.53×10−08
cg0291000216 ADCY7 South Shelf−0.002620.0484.85×10−14 3.82×10−08
cg0805046420IntergenicSouth Shore−0.271780.0431.84×10−10 2.42×10−05
  • *Chromosome.

  • FDR, false discovery rate.