Table 1

Subject characteristics of fibroblasts of combined groups and subgroups

VariableControlCOPDP valueVariableControl (SEO-COPD-matched)SEO-COPDP valueControl (older COPD-matched)Older, mild-moderate COPDP value
Number1921Number9101011
Age, mean years (range)61 (42–81)62 (44–81)0.844Age, mean years (range)52 (42–59)50 (44–55)0.34970 (65–81)73 (66–81)0.176
Male/female, n9/1012/90.548Male/female, n1/82/80.5568/210/10.500
Pack-years34 (28–40)30 (15–50)0.627Pack-years32 (28–35)26 (14–30)0.67343 (28–51)49 (19–53)0.823
Stop-months,120 (30–240)78 (36–96)0.337Stop-months84 (18–168)78 (63–93)0.677186 (81–252)66 (27–96)0.421
Non-COPD, n19Non-COPD, n910
COPD, n21COPD, n1011
 GOLD 1 GOLD 1
 GOLD 27 GOLD 27
 GOLD 34 GOLD 34
 GOLD 410 GOLD 410
FEV1 %pred88.1 (82.5–98.0)38.8 (17.1–66.7) 0.000 FEV1 %pred87.0 (83.5–92.0)16.5 (14.3–22.7) 0.000 90.7 (82.2–104.0)66.7 (43.4–70.5) 0.000
FVC %pred90.3 (83.0–107.5)77.9 (44.2–83.5) 0.005 FVC %pred92.8 (84.6–101.0)42.6 (37.9–68.1) 0.000 89.5 (76.7–107.5)83.5 (79.7–98.8)0.647
FEV1/FVC73.6 (71.8–77.7)41.8 (28.4–50.0) 0.000 FEV1/FVC75.9 (73.3–79.0)27.6 (26.0–38.5) 0.000 72.1 (70.3–75.1)50.0 (41.7–59.0) 0.000
  • Data are presented as medians with interquartile ranges unless otherwise stated.

  • Significant differences between groups were tested using Mann–Whitney U tests or unpaired t-tests. P values are stated.

  • Gold stage based on FEV1 %pred.

  • %pred, % predicted; SEO, severe, early-onset.