Characteristics of screen-detected subsolid nodules diagnosed as lung cancer
| Total (n=227) | Baseline subsolid nodule (n=210) | New subsolid nodule (n=17) | P value* | |
| Nodule type at first detection, n (%) | 0.077 | |||
| Pure GGN | 76 (33.5) | 67 (31.9) | 9 (52.9) | |
| Part solid | 151 (66.5) | 143 (68.1) | 8 (47.1) | |
| Diameter at first detection (mm), mean±SD | 12.8±7.0 | 12.3±6.8 | 11.8±9.2 | 0.665 |
| Histological classification, n (%) | 0.680 | |||
| AIS | 31 (13.7) | 30 (14.3) | 1 (5.9) | |
| MIA | 59 (26.0) | 53 (25.2) | 6 (35.3) | |
| Invasive adenocarcinoma | 136 (59.9) | 126 (60.0) | 10 (58.8) | |
| Poorly differentiated NSCLC | 1 (0.4) | 1 (0.5) | 0 (0) | |
| Stage at diagnosis, n (%)† | – | |||
| 0‡ | 31 (13.7) | 30 (14.3) | 1 (5.9) | |
| IA | 175 (77.1) | 160 (76.2) | 15 (88.2) | |
| IB | 12 (5.3) | 11 (5.2) | 1 (5.9) | |
| IIA | 2 (0.9) | 2 (1.0) | 0 (0) | |
| IIB | 1 (0.4) | 1 (0.5) | 0 (0) | |
| IIIA | 1 (0.4) | 1 (0.5) | 0 (0) | |
| IIIB | 0 (0) | 0 (0) | 0 (0) | |
| IIIC | 1 (0.4) | 1 (0.5) | 0 (0) | |
| IV | 4 (1.8) | 4 (1.9) | 0 (0) | |
| Time of biopsy, n (%) | 0.744 | |||
| At first detection | 39 (17.2) | 37 (17.6) | 2 (11.8) | |
| After follow-up | 188 (82.8) | 173 (82.4) | 15 (88.2) | |
| Time from first detection to biopsy (months), mean±SD | 30.8±39.9 | 30.4±39.8 | 36.0±42.9 | 0.608 |
*The p value is based on the comparison between baseline and new nodules.
†Multisynchronous GGNs were considered multiple primary tumours rather than lung-to-lung metastasis.
‡Nodules diagnosed as AIS.
AIS, adenocarcinoma in situ; GGN, ground glass opacity nodule; MIA, minimally invasive adenocarcinoma;NSCLC, non-small-cell lung cancer.