Table 3

Results from sex-separated multinomial logistic regression analyses between specific early-life ACEs (bereavement/parental chronic diseases/parental mental illness or suicide attempt), each examined in a separate model and asthma phenotypes

Asthma phenotypesnCasesOR* (95% CI)nCasesOR* (95% CI)
Children exposed to bereavement (yes vs no)
 No asthma207 6354171207 2674561
 Early-onset transient asthma11 740251.121 (1.01 to 1.23)18 808401.17 (1.08 to 1.26)
 Early-onset persistent asthma351171.27 (1.07 to 1.51)6460151.34 (1.18 to 1.52)
 Late-onset asthma427091.24 (1.05 to 1.46)6865141.03 (0.90 to 1.20)
Children exposed to parental chronic (yes vs no) diseases
 No asthma207 63533911207 26739951
 Early-onset transient asthma11 7402691.14 (0.99 to 1.31)18 8084421.22 (1.09 to 1.36)
 Early-onset persistent asthma3511881.37 (1.09 to 1.73)64601761.38 (1.17 to 1.64)
 Late-onset asthma42701081.32 (1.06 to 1.65)68651471.04 (0.86 to 1.26)
Children exposed to parental mental illness or suicide attempt (yes vs no)
 No asthma207 63536011207 26735641
 Early-onset transient asthma11 7402551.09 (0.95 to 1.25)18 8084121.14 (1.02 to 1.27)
 Early-onset persistent asthma3511761.1920 (0.93 to 1.534)64601381.32 (1.09 to 1.57)
 Late-onset asthma4270861.15 (0.901 to 1.46)68651231.02 (0.83 to 1.25)
  • The response variable is the asthma phenotypes, no asthma is the reference. The population studied comprised of children born in Denmark between 1997 and 2004.

  • *Adjusted for maternal age atdelivery (years), parents' highest educational level at conception, maternal smoking during pregnancy, maternal place of livingat delivery, parity & calendar year of birth and season of birth.

  • ACEs, adverse childhood experiences.