Table 2

Results from sex-separated multinomial logistic regression analyses between cumulative ACEs in early life (0 vs 1, and 0 vs >1) and asthma phenotypes

Asthma phenotypesGirls, n=227 156Boys, n=239 400
nCasesOR* (95% CI)nCasesOR* (95% CI)
Children who had experienced 1 vs 0 ACE
 No asthma207 63574131207 26774301
 Early-onset transient asthma11 7405081.12 (1.01 to 1.24)18 8088321.17 (1.08 to 1.27)
 Early-onset persistent asthma35111551.25 (1.05 to 1.50)64603061.34 (1.18 to 1.52)
 Late-onset asthma42701901.24 (1.05 to 1.47)68652671.04 (0.90 to 1.20)
Children who had experienced >1 vs 0 ACE
 No asthma207 6353651207 2673581
 Early-onset transient asthma11 740241.08 (0.69 to 1.69)18 808391.15 (0.81 to 1.64)
 Early-onset persistent asthma3511101.77 (0.91 to 3.44)6460141.40 (0.80 to 2.44)
 Late-onset asthma427081.21 (0.57 to 2.56)6865110.96 (0.49 to 1.86)
  • The response variable is the asthma phenotypes, and no asthma is the reference. The population studied comprised of children born in Denmark between 1997 and 2004.

  • *Adjusted for maternal age at delivery(years), parents highest educational level at conception, maternal smoking during pregnancy, maternal place of living at delivery,parity & calendar year of birth and season of birth.

  • ACE, adverse childhood experiences.