Table 1

Blood markers of coagulation, fibrinolysis and inflammation in COVID-19

Blood testDirection of changeComparator
(case vs control)		Reference(s)
D-dimer↑Severe versus non-severe 17
Fibrinogen↑ICU versus ref range 16
Platelets→ / ↓Severe versus non-severe 17 101
aPTT→Severe versus non-severe 17 90
PT→ / ↑Severe versus non-severe 17 102
Antithrombin→ / ↑COVID-19 versus healthy control 103
PAI-1↑Autopsy versus ref range 43
Leucocytes↑Severe versus non-severe 17
Lymphocytes↓Severe versus non-severe 17
Neutrophils↑Severe versus non-severe 17
Factor VIII↑ICU versus non-ICU 39
VWF↑ICU versus non-ICU 39
Soluble P-selectin↑ICU versus non-ICU 39
CRP↑Severe versus non-severe 17
Procalcitonin↑Severe versus non-severe 17 90
Ferritin↑Severe versus non-severe 90
Complement↑Autopsy versus ref range 64

  • Arrows indicate the direction of change (↑=increase, ↓=decrease, →=no change) in COVID-19 with respect to a control group or reference range defined in the comparator column. The magnitude of change (ie, marked increase vs mild increase) is not indicated in this table.

  • aPTT, activated partial thromboplastin time; CRP, C reactive protein; ICU, intensive care unit; PAI-1, plasminogen activator inhibitor 1; PT, prothrombin time; ref, reference; VWF, von Willebrand factor.