Table 1

Predictors of dyspnoea severity, abnormal DLCO and CT abnormalities 12 weeks after symptom onset

Unadjusted analysisAdjusted analysis
(at 12 weeks)
Primary predictorCoefficient95% CIP valueCoefficient95% CIP valuePrespecified covariates
1UCSD*Days on oxygen supplementation0.17−0.19 to 0.520.350.19−0.17 to 0.550.29Sex, age, BMI
Days on oxygen supplementation−0.49−0.83 to −0.150.01−0.44−0.77 to −0.110.01Sex, age
3Total CT score (extent of reticulation+ground glass)†Days on oxygen supplementation0.810.56 to 1.07<0.0010.770.52 to 1.02<0.001Sex, age
UCSD at 12 weeks−0.46−0.73 to −0.180.002−0.39−0.65 to −0.130.005Sex, age, days on oxygen
  • Models 1–3 test the association of the outcome variable with the primary predictor variables that were available at the time of hospital discharge. Model 4 tests the association of the outcome variable with data that were available postdischarge in outpatient setting.

  • *UCSD: higher score represents worse dyspnoea (range 0–120).

  • †HRCT scores were determined by separating each lung into three zones and determining the per cent of lung affected by either ground glass or reticulation. The average scores from the six zones were then used to determine the total reticulation and ground glass scores for each patient, with the sum of these used to determine the total HRCT score.

  • BMI, body mass index; DLCO, diffusion capacity of the lung for carbon monoxide; HRCT, high-resolution CT; UCSD, University of California San Diego shortness of breath questionnaire.