Table 4

Outcomes in current ACE-I/ARB users compared with ACE-I/ARB non-users aged 50+ years and compared with CCB users

OutcomeExposedUnexposedComparison
EventsRisk (%)EventsRisk (%)Risk difference (%)Relative risk
Current ACE-I/ARB users compared with current CCB users
Unweighted cohort
Death126/106511.8 (9.9–13.8)43/28914.9 (10.8–19.0)−3.0 (−7.6–1.5)0.80 (0.58–1.10)
ICU admission66/10596.2 (4.8–7.7)16/2885.6 (2.9–8.2)0.7 (−2.3–3.7)1.12 (0.66–1.91)
Mechanical ventilation51/10654.8 (3.5–6.1)16/2895.5 (2.9–8.2)−0.7 (−3.7–2.2)0.86 (0.50–1.49)
Hospital admission361/100136.1 (33.1–39.0)125/27345.8 (39.9–51.7)−9.7 (−16.3–-3.1)0.79 (0.68–0.92)
Acute dialysisNANANANA0.2 (−1.4–1.8)1.13 (0.38–3.35)
IPTW cohort
Death131/106512.3 (10.3–14.4)40/28513.9 (9.2–18.6)−1.5 (−6.7–3.6)0.89 (0.61–1.30)
ICU admission66/10586.3 (4.8–7.8)15/2835.4 (2.3–8.4)0.9 (−2.4–4.3)1.17 (0.64–2.16)
Mechanical ventilation52/10654.8 (3.5–6.2)17/2855.9 (2.6–9.2)−1.1 (−4.6–2.5)0.82 (0.44–1.53)
Hospital admission366/100136.5 (33.5–39.6)118/27443.3 (36.0–50.6)−6.7 (−14.7–1.2)0.84 (0.70–1.02)
Acute dialysisNANANANA0.7 (−0.7–2.0)1.62 (0.53–4.92)
Current ace-i/ARB users compared with ace-i/ARB non-users aged 50 years or older
Unweighted cohort
Death166/133612.4 (10.7–14.2)367/43268.5 (7.7–9.3)3.9 (2.0–5.9)1.46 (1.23–1.74)
ICU admission104/13297.8 (6.4–9.3)166/43213.8 (3.3–4.4)4.0 (2.4–5.5)2.04 (1.61–2.58)
Mechanical ventilation81/13366.1 (4.8–7.3)121/43262.8 (2.3–3.3)3.3 (1.9–4.6)2.17 (1.65–2.85)
Hospital admission507/125840.3 (37.6–43.0)1097/419226.2 (24.8–27.5)14.1 (11.1–17.2)1.54 (1.42–1.68)
Acute dialysis27/13252.0 (1.3–2.8)37/43090.9 (0.6–1.1)1.2 (0.4–2.0)2.37 (1.45–3.88)
IPTW cohort
Death112/11799.5 (7.5–11.5)512/473810.8 (9.1–12.5)−1.3 (−3.9–1.3)0.88 (0.68–1.14)
ICU admission75/11736.4 (4.7–8.1)243/47335.1 (2.2–8.1)1.3 (−2.1–4.7)1.25 (0.66–2.36)
Mechanical ventilation62/11795.3 (3.7–6.9)201/47384.2 (1.3–7.2)1.0 (−2.3–4.4)1.24 (0.58–2.66)
Hospital admission362/111832.3 (28.8–35.9)1505/454633.1 (29.5–36.7)−0.8 (−5.8–4.3)0.98 (0.84–1.14)
Acute dialysis27/11722.3 (1.1–3.5)36/47100.8 (0.5–1.0)1.6 (0.3–2.8)3.04 (1.64–5.65)
  • ACE-I, ACE inhibitors; ARB, angiotensin receptor blocker; CCB, calcium channel blocker; ICU, intensive care unit; IPTW, inverse probability of treatment weighting; NA, not available.