Table 1

Included studies with study characteristics and sample size for treatment (Tx) and control group (control) shown

Author, yearDrugN, Tx/controlStudy countryCentreStudy designAuthor, yearDrugN, Tx/controlStudy countryCentreStudy designAuthor, yearDrugN, Tx/
control
Study countryCentreStudy design
Balkhair et al, 202026A45/24OmanSingle centreProspective with controlRoumier et al, 202032T49/47FranceSingle centreProspective with controlKimmig et al, 202033T54/57USASingle centreRetrospective
Huet et al, 202029A52/44FranceSingle centreProspective with controlSalama et al, 202022T249/
128
USAMulticentreDouble-blind RCTKlopfenstein et al, 202034T20/25FranceSingle centreRetrospective
Kooistra et al, 202035A21/39NetherlandsMulticentreProspective with controlSalvarani et al, 202036T60/63ItalyMulticentreOpen-label RCTLewis et al, 202037T497/497USAMulticentreRetrospective
*Kyriazopoulou et al, 202028A130/130GreeceMulticentreProspective*Sanchez-Montalva et al, 202038T82/0SpainSingle centreProspectiveMartinez-Sanz et al, 202039T260/969SpainMulticentreRetrospective
Cauchois et al, 202024A12/10FranceMulticentreRetrospectiveSciascia et al, 202040T63/0ItalyMulticentreProspectiveNarain et al, 202027T73/3076USAMulticentreRetrospective
Cavalli et al, 202025A29/16ItalySingle centreRetrospectiveStone et al, 202021T161/
82
USAMulticentreDouble-blind RCTNasa et al, 202041T22/63IndiaMulticentreRetrospective
Narain et al, 202027A57/3076USAMulticentreRetrospectiveStrohbehn et al, 202042T32/41USASingle centrePhase II
open label
Patel et al, 202043T60/1505USASingle centreRetrospective
Benucci et al, 202044Sa8/0ItalySingle centreProspectiveToniati et al, 202045T100/0ItalySingle centreProspective*Petrak et al, 202046T81/37USAMulticentreRetrospective
Della-Torre et al, 202030Sa28/28ItalySingle centreProspective with controlBiran et al, 202047T210/
420
USAMulticentreRetrospectivePettit et al, 202048T42/41USASingle centreRetrospective
*Gordon et al, 202120Sa45/397UKMulticentreAdaptive RCTCanziani et al, 202049T64/64ItalyMulticentreRetrospectivePotere et al, 202050T74/74ItalySingle centreRetrospective
Gremese et al, 202051Sa53/0ItalySingle centreProspectiveCapra et al, 202052T62/23ItalySingle centreRetrospective*Ramaswamy et al, 202053T10/10USAMulticentreRetrospective
Sinha et al, 202054Sa255/0USASingle centreProspectiveChilimuri et al, 202055T83/
685
USASingle centreRetrospectiveRodríguez-Baño et al, 202056T21/65SpainMulticentreRetrospective
*Gritti et al, 202031Si30/30ItalySingle centreProspective with controlDe Rossi et al, 202057T90/68ItalySingle centreRetrospectiveRojas-Marte et al, 202058T88/344USASingle centreRetrospective
Albertini et al, 202059T22/22FranceSingle centreProspective with controlEimer et al, 202060T22/22SwedenSingle centreRetrospectiveRoomi et al, 202061T96/97USASingle centreRetrospective
Antony et al, 202062T80/0USAMulticentreProspectiveFisher et al, 202063T45/70USASingle centreRetrospectiveRosas et al, 202064T20/17SpainSingle centreRetrospective
Campins et al, 202065T58/0SpainSingle centreProspectiveGalván-Román et al, 202066T58/88SpainSingle centreRetrospectiveRossi et al, 202067T84/84FranceSingle centreRetrospective
*Carvalho et al, 202068T29/24BrazilSingle centreProspective with control*Moreno Garcia et al, 202069T77/94SpainSingle centreRetrospectiveRossotti et al, 202070T74/148ItalySingle centreRetrospective
Dastan et al, 202071T42/0IranSingle centreProspectiveGokhale et al, 202072T70/91IndiaSingle centreRetrospectiveRuiz-Antorán et al, 202073T268/238SpainMulticentreRetrospective
*Gordon et al, 202120T350/397UKMulticentreAdaptive RCTGuaraldi et al, 202074T179/
365
ItalyMulticentreRetrospectiveSomers et al, 202075T78/76USASingle centreRetrospective
Hermine et al, 202023T63/67FranceMulticentreOpen-label RCTGuisado-Vasco et al, 202076T132/
475
SpainSingle centreRetrospectiveTian et al, 202077T65/130ChinaMulticentreRetrospective
Malekzadeh et al, 202078T126/0IranMulticentreProspectiveGupta et al, 202079T433/
3492
USAMulticentreRetrospectiveTsai et al,
202080
T66/66USASingle centreRetrospective
Mikulska et al, 202081T29/66ItalySingle centreProspective with controlHill et al, 202082T43/45USASingle centreRetrospective*Wadud et al, 202083T84/84USASingle centreRetrospective
Morena et al, 202084T51/0ItalySingle centreProspectiveHolt et al, 202085T24/30USASingle centreRetrospectiveZheng et al, 202086T92/89ChinaSingle centreRetrospective
Perrone et al, 202087T708/481ItalyMulticentreSingle-arm open label and validationIp et al, 202088T134/413USAMulticentreRetrospective
*Rosas et al, 202089T294/144USAMulticentreDouble-blind RCTKewan et al, 202090T28/23USASingle centreRetrospective
  • *Non-peer-reviewed preprint study.

  • A, anakinra; RCT, randomised clinical trial; Sa, sarilumab; Si, siltuximab; T, tocilizumab.