Baseline demographics of the study population, presented by genotype
| n | MZ | SZ | ZZ | P value | ||
| 156 | 117 | 213 | SZ vs MZ | MZ vs ZZ | SZ vs ZZ | |
| Age (Y) | 51 (41.75 to 63.0) | 51 (36.0 to 59.0) | 49 (41.0 to 57.0) | 0.134 | 0.027 | 0.563 |
| Diagnosis age (Y) | 49.5 (39.0 to 60.3) | 50 (37.0 to 59.0) | 48 (38.0 to 55.0) | 0.604 | 0.07 | 0.209 |
| Sex=male (%) | 65 (41.7) | 56 (47.9) | 118 (55.4) | 0.307 | 0.009 | 0.189 |
| Lung index (%) | 81 (51.9) | 51 (43.6) | 131 (61.5) | 0.173 | 0.065 | 0.001 |
| Ever-smokers (%) | 92 (59.0) | 61 (52.1) | 134 (62.9) | 0.259 | 0.443 | 0.057 |
| AAT level (g/L) | 0.83 (0.74 to 0.93) | 0.59 (0.51 to 0.71) | 0.25 (0.20 to 0.30) | <0.001 | <0.001 | <0.001 |
| Height (cm) | 166.8 (9.8) | 169.3 (10.7) | 170.7 (8.9) | 0.049 | <0.001 | 0.212 |
| Weight (kg) | 75.3 (63.0 to 88.1) | 78 (65.0 to 91.5) | 76 (65.7 to 86.1) | 0.42 | 0.822 | 0.4 |
| BMI (kg/m2) | 26 (23.0 to 30.4) | 27 (23.0 to 30.5) | 25.9 (22.6 to 29.0) | 0.998 | 0.12 | 0.119 |
| FEV1pp | 91.3 (70.0 to 109.0) | 95 (83.0 to 107.0) | 68 (41.0 to 99.0) | 0.278 | <0.001 | <0.001 |
| FVCpp | 106 (92.0 to 117.3) | 104 (95.0 to 117.0) | 101 (82.8 to 113.3) | 0.976 | 0.018 | 0.022 |
| FEV1/FVC | 0.72 (0.61 to 0.81) | 0.76 (0.68 to 0.80) | 0.56 (0.41 to 0.77) | 0.085 | <0.001 | <0.001 |
| DLCOpp ⃰ (n=293) | 84 (72.5 to 92.0) | 86 (71.0 to 96.0) | 68.5 (51.0 to 88.8) | 0.417 | 0.001 | <0.001 |
| Never-smokers | 64 | 56 | 79 | |||
| FEV1pp | 103 (81.8 to 110.3) | 101.5 (91.0 to 111.0) | 93 (68.5 to 103.5) | 0.251 | 0.046 | 0.002 |
| FVCpp | 107.5 (92.8 to 116.3) | 108 (97.8 to 117.0) | 106 (90.0 to 115.0) | 0.662 | 0.291 | 0.148 |
| FEV1/FVC | 0.77 (0.67 to 0.83) | 0.77 (0.72 to 0.84) | 0.73 (0.57 to 0.82) | 0.274 | 0.28 | 0.023 |
| DLCOpp ⃰ (n=135) | 84 (78.0 to 95.0) | 89 (77.5 to 100.0) | 84 (67.0 to 100.5) | 0.23 | 0.884 | 0.246 |
| Ever-smokers | 92 | 61 | 134 | |||
| Pack-years | 18 (8.2 to 46.3) | 16 (7.5 to 37.5) | 18 (6.5 to 30.9) | 0.783 | 0.258 | 0.423 |
| FEV1pp | 86.5 (62 to 105.0) | 86 (71.0 to 98.0) | 52.5 (37.0 to 86.0) | 0.985 | <0.001 | <0.001 |
| FVCpp | 105.5 (88.3 to 118.0) | 101.0 (92.0 to 115.0) | 98.0 (80.0 to 113.0) | 0.652 | 0.05 | 0.132 |
| FEV1/FVC | 0.69 (0.56 to 0.77) | 0.72 (0.59 to 0.78) | 0.47 (0.38 to 0.67) | 0.512 | <0.001 | <0.001 |
| DLCOpp ⃰ (n=158) | 82 (68.5 to 90.0) | 83.0 (64.3 to 93.5) | 57 (45.0 to 77.0) | 0.926 | <0.001 | <0.001 |
Data are presented as mean (±SD) for parametric, median + (IQR) for non-parametric and number (%) for categorical. Bold values signify Bonferroni-adjusted significance threshold p<0.004.
AAT, alpha-1 antitrypsin; BMI, body mass index; DLCO, diffusion capacity for Carbon Monoxide; FEV1/FVC, ratio of FEV1 to FVC; pp, percentage predicted.