Asthma outcomes at 3 months for 114 participants
| Intervention n=55 | Standard care n=59 | Comparison | |
| Primary outcome: cACT score | |||
| cACT score, mean (SD) | 22.9 (2.3) | 20.8 (3.0) | p<0.001 |
| Change in cACT score from baseline, mean (SD) | 2.7 (2.8) | 0.6 (2.8) | p<0.001 |
| Stratified: baseline cACT ≤19 | 4.7 (2.6) n=21 | 1.1 (3.0) n=21 | p<0.001 |
| Stratified: baseline cACT ≥20 | 1.5 (2.2) n=34 | 0.3 (2.7) n=38 | p=0.046 |
| Secondary outcomes | |||
| Healthcare use | |||
| Exacerbations with hospitalisation, n (%) | 2 (3.6) | 6 (10.2) | p=0.32 |
| Exacerbations with health facility attendance but not admission, n (%) | 3 (5.5) | 11 (18.6) | p=0.06 |
| Exacerbations with any emergency healthcare use, n (%) | 4 (7.3) | 15 (25.4) | p=0.019 |
| School absence | |||
| School absence, n (%) | 11 (20.0) | 37 (62.7) | p<0.001 |
| Pre-bronchodilator lung function | |||
| Mean (SD) % predicted FEV1* | 86.9 (18.0) | 92.0 (17.5) | p=0.15 |
| Mean (SD) % predicted FEV1/FVC ratio† | 90.9 (12.5) | 92.8 (10.3) | p=0.42 |
| FEV1/FVC ratio below LLN, n (%)† | 15/47 (31.9) | 13/45 (28.9) | p=0.93 |
| Fractional concentration of exhaled nitric oxide (FeNO) | |||
| Median (IQR) FeNO, ppb ‡ | 41.8 (23.4–68.0) | 39.8 (22.9–57.9) | p=0.64 |
| High (>35 ppb), n (%) | 33 (58.9) | 31 (55.4) | p=0.85 |
| Intermediate (20–35 ppb), n (%) | 11 (19.6) | 15 (26.8) | p=0.50 |
| Low (<20 ppb), n (%) | 12 (21.4) | 10 (17.9) | p=0.81 |
*Technically acceptable FEV1 data available for 99 participants.
†Technically acceptable FEV1/FVC data available for 92 participants.
‡FeNO data available for 112 participants.
cACT, Childhood Asthma Control Test; LLN, lower limit of normal.