Table 2

OR for individual symptoms in current smokers versus non-smokers

N
(non-smokers/smokers)
Standard users
2 221 088
(220 135/1 819 505)
COVID-19
self-reported
157 406
(18 845/117 848)
SARS-CoV-2
tested –
16 759
(1418/13 902)
SARS-CoV-2
tested +
7123
(472/5908)
SymptomOR (95% CI)P valueOR (95% CI)P valueOR (95% CI)P valueOR (95% CI)P value
Abdominal pain1.35 (1.33 to 1.38)8.35×10–1981.43 (1.37 to 1.50)7.21×10–571.33 (1.13 to 1.56)6.94×10–41.43 (1.15 to 1.77)1.07×10–3
Chest pain1.16 (1.14 to 1.18)1.42×10–631.10 (1.06 to 1.14)4.04×10–61.06 (0.92 to 1.23)4.06×10–11.31 (1.07 to 1.62)1.08×10–2
Delirium1.22 (1.20 to 1.25)2.12×10–931.26 (1.20 to 1.31)1.08×10–231.60 (1.34 to 1.89)8.09×10–81.83 (1.47 to 2.27)4.38×10–8
Diarrhoea1.31 (1.29 to 1.33)3.94×10–2101.28 (1.23 to 1.34)5.59×10–291.31 (1.12 to 1.53)5.55×10–41.14 (0.92 to 1.40)2.34×10–1
Fatigue1.06 (1.05 to 1.08)1.75×10–150.94 (0.90 to 0.99)1.40×10–21.00 (0.84 to 1.18)9.55×10–10.78 (0.57 to 1.10)1.46×10–1
Fever1.01 (0.98 to 1.03)6.37×10–11.01 (0.96 to 1.06)8.42×10–10.87 (0.74 to 1.02)8.79×10–20.86 (0.70 to 1.06)1.54×10–1
Headache1.10 (1.08 to 1.12)1.91×10–251.30 (1.24 to 1.36)2.77×10–251.03 (0.87 to 1.22)7.23×10–11.08 (0.83 to 1.41)5.89×10–1
Hoarse voice1.06 (1.04 to 1.08)8.38×10–81.06 (1.01 to 1.10)1.04×10–20.95 (0.81 to 1.12)5.48×10–11.19 (0.97 to 1.46)1.02×10–1
Anosmia1.07 (1.05 to 1.09)6.98×10–110.88 (0.85 to 0.92)4.82×10–91.18 (0.99 to 1.39)5.55×10–20.93 (0.74 to 1.17)5.32×10–1
Persistent cough1.18 (1.16 to 1.20)8.28×10–900.99 (0.95 to 1.03)5.31×10–10.88 (0.76 to 1.01)7.27×10–20.73 (0.59 to 0.90)2.96×10–3
Shortness of breath1.16 (1.14 to 1.18)3.34×10–711.09 (1.05 to 1.14)1.40×10–51.11 (0.96 to 1.29)1.40×10–11.35 (1.09 to 1.68)6.53×10–3
Skipped meals1.76 (1.73 to 1.79)p<2.23e-3081.52 (1.46 to 1.59)4.78×10–881.46 (1.26 to 1.70)6.92×10–71.31 (1.06 to 1.61)1.15×10–2
Sore throat0.93 (0.91 to 0.95)2.04×10–141.17 (1.12 to 1.23)2.00×10–110.90 (0.77 to 1.06)2.12×10–11.32 (1.06 to 1.65)1.30×10–2
Unusual muscle pains1.47 (1.43 to 1.52)2.41×10–1511.46 (1.37 to 1.55)8.90×10–301.24 (1.02 to 1.50)3.18×10–21.19 (0.94 to 1.51)1.40×10–1
  • For each test group, the table reports the OR (95% CI) and p value of the association between smoking status and individual COVID-19 symptoms, adjusted for age, sex and BMI. An OR >1 reflects an increased likelihood of this symptom being reported in current smokers. Associations passing Bonferroni correction for multiple testing (p<1.14×10−3) are highlighted in bold.