Table 1

Blood markers of coagulation, fibrinolysis and inflammation in COVID-19

Blood test	Direction of change	Comparator (case vs control)	Reference(s)
D-dimer	↑	Severe versus non-severe	17
Fibrinogen	↑	ICU versus ref range	16
Platelets	→ / ↓	Severe versus non-severe	17 101
aPTT	→	Severe versus non-severe	17 90
PT	→ / ↑	Severe versus non-severe	17 102
Antithrombin	→ / ↑	COVID-19 versus healthy control	103
PAI-1	↑	Autopsy versus ref range	43
Leucocytes	↑	Severe versus non-severe	17
Lymphocytes	↓	Severe versus non-severe	17
Neutrophils	↑	Severe versus non-severe	17
Factor VIII	↑	ICU versus non-ICU	39
VWF	↑	ICU versus non-ICU	39
Soluble P-selectin	↑	ICU versus non-ICU	39
CRP	↑	Severe versus non-severe	17
Procalcitonin	↑	Severe versus non-severe	17 90
Ferritin	↑	Severe versus non-severe	90
Complement	↑	Autopsy versus ref range	64

Arrows indicate the direction of change (↑=increase, ↓=decrease, →=no change) in COVID-19 with respect to a control group or reference range defined in the comparator column. The magnitude of change (ie, marked increase vs mild increase) is not indicated in this table.
aPTT, activated partial thromboplastin time; CRP, C reactive protein; ICU, intensive care unit; PAI-1, plasminogen activator inhibitor 1; PT, prothrombin time; ref, reference; VWF, von Willebrand factor.