Table 3

Most significant differentially methylated positions for baseline FEV₁ and FEV₁/FVC

Trait	Probe	Chr*	Gene	Relation to Island	Beta	SE	P value	FDR
FEV₁	cg09006039	4	Intergenic	Open Sea	94.41	17.42	6.05×10⁻⁰⁸	9.54×10⁻⁰³
	cg22040274	5	Unknown	Open Sea	−127.22	22.38	1.32×10⁻⁰⁸	2.74×10⁻⁰³
	cg01557460	11	MACROD1	North Shore	−53.31	9.31	1.06×10⁻⁰⁸	2.74×10⁻⁰³
	cg17903071	14	DPF3	Island	−850.63	147.35	7.79×10⁻⁰⁹	2.74×10⁻⁰³
	cg23599559	17	CACNA1G	Island	−302.09	53.24	1.39×10⁻⁰⁸	2.74×10⁻⁰³
FEV₁/FVC ratio	cg16091981	1	PADI4	Open Sea	−0.0223	0.003	7.38×10⁻¹²	1.94×10⁻⁰⁶
	cg02703606	3	DLEC1	Open Sea	−0.0134	0.002	1.19×10⁻¹⁰	2.35×10⁻⁰⁵
	cg03045038	11	FERMT3	North Shore	−0.0094	0.001	7.38×10⁻¹²	1.94×10⁻⁰⁶
	cg26615186	16	Unknown	Open Sea	−0.0088	0.001	1.70×10⁻¹⁰	2.68×10⁻⁰⁵
	cg06100973	19	ELANE	North Shore	−0.0085	0.001	1.49×10⁻¹²	1.17×10⁻⁰⁶

*Chromosome.
FDR, false discovery rate.