Change in anchors across tertiles of change in EQ-5D-5L over 6 months
| Tertiles of change in EQ-5D-5L | Tertile 1 (decrease in EQ-5D-5L) | Tertile 2 (minimal change) | Tertile 3 (increase in EQ-5D-5L) |
| SGRQ | Mean ∆: −15 | Mean ∆: 0.72 | Mean ∆: 20 |
| ∆ reported in EQ-5D-5L | 0.06±0.16 | 0.01±0.12 | −0.03±0.14 |
| ∆ reported in EQ-VAS | 4.4±15.9 | −1±12.2 | −6.1±18.0 |
| UCSDSOBQ | Mean ∆: −13 | Mean ∆: 2 | Mean ∆: 22 |
| ∆ reported in EQ-5D-5L | 0.05±0.14 | 0.004±0.11 | −0.05±0.16 |
| ∆ reported in EQ-VAS | 3.7±17.1 | 0.1±13.0 | −4.9±18.3 |
| FVC | Mean ∆: −9 | Mean ∆: −1 | Mean ∆: 5 |
| ∆ reported in EQ-5D-5L | −0.03±0.15 | 0.01±0.13 | 0.03±0.15 |
| ∆ reported in EQ-VAS | −1.3±17.5 | 0.07±16.2 | 0.6±16.1 |
| DLCO | Mean ∆: −12 | Mean ∆: −2 | Mean ∆: 5 |
| ∆ reported in EQ-5D-5L | −0.02±0.13 | 0.03±0.14 | 0.01±0.11 |
| ∆ reported in EQ-VAS | −1.5±16.4 | −0.8±13.9 | 1.9±15.8 |
| 6MWD | Mean ∆: −55 | Mean ∆: 4 | Mean ∆: 59 |
| ∆ reported in EQ-5D-5L | −0.02±0.10 | 0.01±0.10 | 0.01±0.13 |
| ∆ reported in EQ-VAS | −2.2±15.7 | 0.8±11.6 | 0.2±14.5 |
Data shown are mean±SD for the 636 patients with 6-month follow-up.
DLCO, diffusing capacity of the lung for carbon monoxide; EQ-5D-5L, European Quality of Life 5-Dimensions 5-Levels questionnaire; EQ-VAS, European Quality of Life Visual Analogue Scale; FVC, forced vital capacity; MID, minimum important difference; 6MWD, 6-minute walk distance; SEM, SE measurement; SGRQ, St. George’s Respiratory Questionnaire; UCSDSOBQ, University of California, San Diego Shortness of Breath Questionnaire.