Anchor-based and distribution-based estimates of the MID for EQ-5D-5L and EQ-VAS
| Anchor-based MID | |||
| EQ-5D-5L | Linear regression equation | MID for anchor | EQ-5D-5L MID |
| SGRQ | EQ-5D-5L=1.054–0.007*SGRQ | 5–8 | 0.034–0.054 |
| UCSDSOBQ | EQ-5D-5L=0.951–0.005*UCSDSOBQ | 5 | 0.024 |
| FVC | EQ-5D-5L=0.587+0.00251*FVC | 2%–6% | 0.0050–0.015 |
| DLCO | EQ-5D-5L=0.646+0.00245*DLCO | 11% | 0.027 |
| 6MWD | EQ-5D-5L=0.585+0.00048*6MWD | 20.7–35.4 m | 0.0099–0.017 |
| EQ-VAS | Linear regression equation | MID for anchor | EQ-VAS MID |
| SGRQ | EQ-VAS=94.02–0.63*SGRQ | 5–8 | 3.15–5.04 |
| UCSDSOBQ | EQ-VAS=83.24–0.42*UCSDSOBQ | 5 | 2.09 |
| FVC | EQ-VAS=48.01+0.27*FVC | 2%–6% | 0.53–1.60 |
| DLCO | EQ-VAS=53.62+0.27*DLCO | 11% | 2.95 |
| 6MWD | EQ-VAS=49.49+0.047*6MWD | 20.7–35.4 m | 0.97–1.66 |
| Distribution-based MID | |||
| SEM | One-half SD | ||
| EQ-5D-5L | 0.078 | 0.095 | |
| EQ-VAS | 8.0 | 9.7 | |
DLCO, diffusing capacity of the lung for carbon monoxide; EQ-5D-5L, European Quality of Life 5-Dimensions 5-Levels questionnaire; EQ-VAS, European Quality of Life Visual Analogue Scale; FVC, forced vital capacity; MID, minimum important difference; 6MWD, 6-minute walk distance; SEM, SE measurement; SGRQ, St. George’s Respiratory Questionnaire; UCSDSOBQ, University of California, San Diego Shortness of Breath Questionnaire.