Table 1

Patients’ baseline demographic and clinical characteristics, and clinical and laboratory data at RICU admission

All cases (n=28)Success group (n=19)Failure group (n=9)P value
Clinical and demographic features
 Age (years), median (min–max)69 (42–87)67 (42–84)80 (64–87)0.0543
 Gender (males/females)21/713/68/10.2513
 No of smokers6 (21.4%)3 (15.7%)3 (33.3%)0.2995
 No of patients with comorbidities20 (71.4%)13 (68.4%)7 (77.8%)0.5286
 No of comorbidities per patient, median (min–max)1 (0–4)1 (0–4)2 (0–4)0.3922
Clinical and laboratory data at RICU admission
 Respiratory rate (breaths/min), median (min–max)26 (12–40)24 (12–40)26 (15–36)0.6950
 Heart rate (beats/min), median (min–max)77 (59–105)77 (59–89)77.5 (62–150)0.6362
 No of patients with fever (temperature >38°C)11 (21.4%)6 (31.6%)5 (55.6%)0.2770
 No of patients with leucopenia (WBC <4400×106/L)3 (10.7%)3 (15.7%)0 (0%)0.2154
 PaO2 (mm Hg), median (min–max)57 (36.2–67.1)58.3 (36.2–67.1)55.5 (39.9–61)0.1224
 PaCO2 (mm Hg), median (min–max)32 (27–45)31.9 (28–45)32.9 (27–39)0.9115
 Arterial pH, median (min–max)7.48 (7.39–7.54)7.49 (7.39–7.52)7.47 (7.40–7.54)0.9357
 SaO2 (%), median (min–max)92 (79–97)93 (79–97)90 (79–94)0.0293
 FiO2, median (min–max)0.6 (0.4–1.0)0.6 (0.4–1.0)0.8 (0.6–1.0)0.0085
 PaO2/FiO2 (mm Hg), median (min–max)108 (52–296)126 (52–296)76 (53–190)0.0194
 No of patients with PaO2/FiO2 ≤10013 (46.4%)6 (31.6%)7 (77.8%)0.0246
 D-dimer (ng/mL), median (min–max)444 (159–259)327 (168–759)727 (159–259)0.1985
 Serum CRP (μg/mL), median (min–max)110 (29–270)110 (29–180)130.0 (110–270)0.0277
 Ferritin (ng/mL), median (min–max)1465.5 (156–5292)1399.5 (156–5292)1465.5 (877–1999)1.000
 SOFA score, median (min–max)2 (2–4)2 (2–4)3 (2–3)0.4610
  • P values refer to differences between HFNC success and HFNC failure groups.

  • CRP, C reactive protein; HFNC, high-flow nasal cannula; PaO2/FiO2, arterial oxygen tension to inspired oxygen fraction ratio; SaO2, arterial oxygen saturation; SOFA, sequential organ failure assessment.