Table 3

Factors associated with mortality in univariate analysis (log-rank) and multivariate analysis (Cox regression)

Univariate analysis (log-rank)Multivariate analysis (Cox regression)
HR (95% CI)P valueHR (95% CI)P value
NIV centre (reference: Rouen)
 London0.903 (0.756 to 1.079)0.3580.944 (0.778 to 1.145)0.560
Gender (reference: male)
 Female0.890 (0.749 to 1.058)0.0980.790 (0.652 to 0.959)0.017
Age (reference: below 60 years old)
 Above 60 years old3.131 (2.336 to 3.297)<0.0012.398 (1.912 to 3.008)<0.001
Underlying respiratory disease (reference: overlap between obstructive airway disease and obstructive sleep apnoea)
 Rapidly progressive neuromuscular disease4.349 (4.095 to 7.906)<0.0014.860 (3.432 to 6.881)<0.001
 Slowly progressive neuromuscular disease0.655 (0.442 to 0.977)0.0380.852 (0.550 to 1.320)0.474
 Obstructive airway disease2.475 (1.771 to 2.988)<0.0012.233 (1.623 to 3.073)<0.001
 Chest wall disease1.016 (0.639 to 1.616)0.09461.169 (0.723 to 1.891)0.524
 Obesity hypoventilation syndrome with or without obstructive sleep apnoea0.633 (0.426 to 0.867)0.0060.721 (0.509 to 1.022)0.066
 Obstructive sleep apnoea0.469 (0.318 to 0.748)0.0010.516 (0.315 to 0.844)0.008
Timing of NIV set-up (reference: elective set-up)
 Set-up following an acute event1.860 (1.545 to 2.203)<0.0011.376 (1.161 to 1.731)0.001
Adherence (reference: below 4 hours per night)
 Adherence above 4 hours per night1.110 (0.903 to 1.376)0.3150.636 (0.512 to 0.790)<0.001
  • NIV, non-invasive ventilation.