Associations between genetically predicted serum total bilirubin and lung cancer incidence by smoking status in white British unrelated participants of UK Biobank
| IRR per 5 μmol/L increase (95% CI) * | P value | Estimated incidence change in 10,000PYs per 5 μmol/L increase (95% CI) * | |
| Overall | 0.90 (0.83 to 0.99) | 0.023 | −0.76 (−1.42 to −0.10) |
| Never smokers | 0.98 (0.78 to 1.22) | 0.87 | −0.04 (−0.49 to 0.41) |
| Former smokers | 0.95 (0.84 to 1.08) | 0.40 | −0.47 (−1.57 to 0.63) |
| Current smokers | 0.83 (0.72 to 0.96) | 0.011 | −6.44 (−11.45 to −1.44) |
| Regular smokers (cigarettes per day) | |||
| Overall† | 0.89 (0.80 to 0.99) | 0.028 | −2.08 (−4.00 to −0.16) |
| Former 1–19 | 1.04 (0.81 to 1.33) | 0.74 | 0.31 (−1.57 to 2.20) |
| Former ≥20 | 0.92 (0.79 to 1.08) | 0.29 | −1.38 (−3.94 to 1.18) |
| Current 1–19 | 0.94 (0.76 to 1.17) | 0.57 | −2.19 (−9.79 to 5.42) |
| Current ≥20 | 0.72 (0.58 to 0.90) | 0.0037 | −23.13 (−38.93 to −7.32) |
*Adjusted for age, gender, calendar year, ethnicity (first 40 principal components), recruitment centre and smoking status. Adjusted and unadjusted incidence rate ratios are reported in online supplementary table S1.
†Adjusted for pack-years, age, gender, calendar year, ethnicity (first 40 principal components), recruitment centre in overall analysis of regular smokers.
IRR, incidence rate ratio.