Table 1

Clinical characteristics and outcomes

PatientPresentationPregnancyPostpregnancy
AgeFeaturemTOR inhibitor treatmentAgeGestation (weeks)DeliveryFetal outcomeMaternal complicationsTreatment and outcome
122TSC, PXSirolimus for 1 year stopped at pregnancy24.628C-section (FD)Premature TSCBilateral pneumothorax, infected pleural space, oxygen dependentAssessed for transplant, not performed.
Sirolimus: 1-year PP
225SOB29.536C-section (MH)HealthyBilateral pneumothoraxSirolimus: 0.8-year PP
330PX36.140NaturalHealthyNoneSirolimus: 0.7-year PP
431PXEverolimus stopped 3 years prior to pregnancy35.037C-section (MH)HealthyPneumothorax, chest drain for 7 weeks, resolved post pregnancy. Pre-eclampsia.
530PX31.840NaturalHealthyNoneSirolimus: 1.2 years PP
633AML35.439C-sectionHealthyNone
729SOB30.934C-section (MH)HealthyBilateral pneumothorax, pleurodesis, deep vein thrombosisSirolimus: 0.4-year PP
824AML, PX26.238C-section (MH)HealthyBilateral pneumothorax and pleurodesisSirolimus: 0.8-year PP
935AML38.536C-section
(FD)
Fetal distressNone
1032AML34.436NaturalHealthyNone
1136PX36.636NaturalHealthyShortness of breathTransplant, died
1232PX37.636C-section (OC)Healthy twinsNone
1331PX34.832C-section (MH)HealthyShort of breathSirolimus: 5.4-year PP
1419TSC, PX25.938C-section (OC)HealthyPre-eclampsiaSirolimus: 1-year PP
1523PXSirolimus for 2.5 years stopped at pregnancy29.840C-section (MH)HealthyNoneSirolimus: 0.75-year PP
1624PX34.440C-section (MH)HealthyNoneSirolimus : 3.25 year PP
  • AML, angiomyolipoma; C-section, caesarean section; FD, fetal distress; MH, mental health; OC, obstetric concern; PP, postpregnancy; PX, pneumothorax; SOB, shortness of breath; TSC, tuberous sclerosis complex.