Controls (n=20) | IPF (n=17) | Chronic HP (n=9) | NSIP (n=9) | Control vs IPF | Control vs chronic HP | Control vs NSIP | |
Age, years | 70 (63–73) (n=18) | 64 (57–71) | 60 (48–67) | 53 (48–65) | p=0.6313 | p=0.0576 | p=0.0254 |
Gender, male/female | 8/12 | 14/3 | 4/5 | 2/7 | p=0.0176 | p>0.9999 | p=0.4311 |
Smoking status, ever/never-smokers | 11/4 | 11/5 | 3/4 | 5/3 | p>0.9999 | p=0.3426 | p=0.657 |
FVC, L | 3.2 (2.6–4.3) (n=18) | 2.6 (2.5–3.3) (n=16) | 1.9 (1.4–2.6) (n=5) | 2.0 (1.5–3.1) (n=6) | p=0.372 | p=0.0077 | p=0.0418 |
FVC % predicted, % | 108.5 (103.5–118.3) | 77.0 (65.8–95.0) | 58.7 (41.0–70.8) | 77.0 (60.2–91.2) | p=0.0009 | p=0.0001 | p=0.0057 |
DLCO, mL/min/mm Hg | 6.3 (5.5–7.4) (n=17) | 4.2 (3.4–5.4) (n=14) | 4.2 (2.1–4.2) (n=5) | 4.2 (3.3–4.6) (n=5) | p=0.0021 | p=0.0009 | p=0.0127 |
DLCO % predicted, % | 80.0 (72.0–88.5) | 54.5 (45.5–62.0) | 55.0 (22.7–55.6) | 56.4 (43.6–57.2) | p=0.0002 | p=0.0003 | p=0.0039 |
Steroid use at baseline yes/no | 3/11 | 1/14 | 3/3 | 3/3 | p=0.3295 | p=0.3027 | p=0.3027 |
Data expressed as median (IQR) unless specified. Age is recorded at time of diagnosis apart from controls whose age is captured at the time of baseline measurements. Groups compared by Kruskal-Wallis test with Dunn’s post hoc test for continuous variables, and by Fisher’s exact test for categorical variables.
DLCO, diffusing capacity for carbon monoxide; HP, hypersensitivity pneumonitis; IPF, idiopathic pulmonary fibrosis; n, number of available data; NSIP, non-specific interstitial pneumonia.