Clinical demographics of study cohort and univariate association with abnormal sound-booth audiometry
| All (n=126) | Normal sound-booth audiometry (n=69) | Abnormal sound-booth audiometry (n=57) | P value univariate analysis | |
| Sex (n (%) female) | 52 (41.3) | 27 (39.1) | 25 (43.8) | 0.59 |
| Chronic Pseudomonas aeruginosa colonisation (n (%)) | 74 (58.7) | 44 (63.8) | 30 (52.6) | 0.46 |
| Previous history of fungal disease treatment (n (%)) | 49 (38.9) | 31 (44.9) | 18 (31.9) | 0.13 |
| Previous history of non-tuberculous mycobacterial treatment (n (%))* | 25 (19.8) | 15 (21.7) | 10 (17.5) | 0.56 |
| Pancreatic insufficiency (n (%)) | 114 (90.5) | 64 (92.8) | 50 (87.7) | 0.34 |
| Chronic rhinosinusitis (n (%)) | 41 (32.5) | 19 (27.5) | 22 (38.6) | 0.19 |
| eGFR (%>90) (n (%)) | 90 (71.4) | 54 (78.2) | 36 (63.2) | 0.05 |
| Maintenance azithromycin (%yes) | 80 (63.5) | 38 (55.1) | 42 (73.7) | 0.03 |
| HHIA score (n (%) abnormal) | 14 (11.1) | 7 (10.1) | 7 (12.3) | 0.70 |
| Tinnitus score (n (%) abnormal) | 12 (9.5) | 6 (8.7) | 6 (10.5) | 0.73 |
| Dizziness score (n (%) abnormal) | 9 (7.1) | 6 (8.7) | 3 (5.3) | 0.46 |
| Age (median (IQR)) | 31.5 (24 to 42) | 30 (24 to 34) | 42 (29 to 49) | <0.0001 |
| FEV1 (median (IQR)) | 2.1 (1.54 to 2.92) | 2.56 (1.7 to 3.07) | 1.85 (1.39 to 2.75) | 0.008 |
| FEV1 % predicted (median (IQR)) | 62 (46 to 80) | 72 (51 to 82) | 61 (46 to 73) | 0.17 |
| BMI (median (IQR)) | 22 (20.1 to 23.8) | 21.5 (20 to 22.6) | 22.3 (20.4 to 24.6) | 0.07 |
| Total days of intravenous antibiotics in the past 10 years (median (IQR)) | 56 (21 to 154) | 56 (28 to 119) | 56 (28 to 182) | 0.03 |
| †Total doses intravenous tobramycin (median (IQR)) | 28 (6 to 75) | 28 (3 to 111) | 28 (7 to 66.5) | 0.08 |
| †Total doses inhaled tobramycin (median (IQR)) | 224 (0 to 2240) | 56 (0 to 1344) | 938 (0 to 3001) | 0.07 |
| †Intravenous amikacin (binary) % | 17.5 | 17.9 | 16.4 | 0.47 |
*Includes any treatment post CF diagnosis.
†Retrospective antimicrobial prescribing data only available in n=114 for preceding 5 years through electronic health records.
BMI, body mass index; eGFR, estimated glomerular filtration rate; FEV1, forced expiratory volume in 1 s; HHIA, Hearing Handicap Inventory for Adults.