Table 2

Top 30 putative miR-27a-5p targets differentially expressed in septic and MSC-treated murine lungs

Gene symbolP value
MSC/CLP
P value
CLP/sham
FC
MSC/CLP
FC
CLP/sham
Gene name
Rbfox35.85E-082.92E-01−2.951.21RNA binding fox-1 homolog 3
Cldn21.45E-075.08E-103.18−4.19Claudin 2
Ace17.69E-063.39E-042.24−2.87ACE I
Prkg28.34E-061.44E-02−1.881.39Protein kinase cGMP-dependent 2
Podxl1.16E-057.07E-06−2.072.12Podocalyxin like
Npr31.71E-054.03E-061.65−1.72Natriuretic peptide receptor 3
Scn3b2.93E-058.53E-012.22−1.03Sodium voltage-gated channel beta subunit 3
Igfbp33.26E-051.54E-032.73−2.10Insulin-like growth factor-binding protein 3
Stmn24.56E-057.67E-08−2.924.43Stathmin 2
Egfr8.15E-051.20E-042.27−2.22Epidermal growth factor receptor
Ehd41.76E-041.10E-07−1.682.18EH domain containing 4
Nrip31.76E-046.36E-052.33−2.49Nuclear receptor interacting protein 3
Kcnh11.85E-044.78E-031.84−1.57K+ voltage-gated channel subfamily H member 1
Vav31.95E-041.41E-062.56−2.82vav guanine nucleotide exchange factor 3
Copg2.15E-042.78E-051.40−1.47Coatomer protein complex subunit gamma 1
Gria12.17E-043.44E-05−1.751.89Glutamate ionotropic Rc AMPA type subunit 1
Fgf72.58E-041.45E-021.78−1.45Fibroblast growth factor 7
Pappa3.01E-046.99E-092.37−4.51Pappalysin 1
Ppm1f3.04E-044.53E-05−1.511.61Protein phosphatase, Mg2+/Mn2+ dependent 1F
Lsm13.70E-048.45E-031.35−1.24LSM1 homologue, mRNA degradation associated
Hspa12b3.77E-044.26E-06−2.162.80Heat shock family A (Hsp70) member 12B
Ndrg15.57E-043.13E-032.42−2.11N-myc downstream regulated 1
Cxcl126.78E-041.89E-10−1.964.15C-X-C motif chemokine ligand 12
Pftk16.98E-041.70E-06−1.672.13Cyclin-dependent kinase 14
Mylk8.14E-041.37E-05−1.732.09Myosin light chain kinase
Frmd68.16E-041.15E-04−1.541.66FERM domain containing 6
Calcrl8.46E-042.26E-03−2.091.96Calcitonin receptor like receptor
Ykt68.85E-048.23E-031.38−1.29YKT6 v-SNARE homologue
Nrf28.97E-048.93E-051.34−1.42Nuclear factor, erythroid 2 like 2
Slc41a29.23E-046.85E-051.71−1.93Solute carrier family 41 member 2
Cxcl149.30E-041.35E-043.34−4.10C-X-C motif chemokine ligand 14
  • cGMP, cyclic guanosine monophosphate; CLP, caecum ligation and puncture; FC, fold change; MSC, mesenchymal stromal cell.